Evidence map›Paper›PMID 29980781›Full record

ReviewNature nanotechnology2018

Advanced tools for the safety assessment of nanomaterials.

Bengt Fadeel, Lucian Farcal, Barry Hardy, Socorro Vázquez-Campos, Danail Hristozov, Antonio Marcomini, Iseult Lynch, Eugenia Valsami-Jones, Harri Alenius, Kai Savolainen

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 310 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. From Nanoparticle Design to Clinical Translation in Cancer Therapy.International journal of molecular sciences · 2026
    Review
  17. Article
  18. Review
  19. Nanomedicine-Based Strategies for Multiple Myeloma Therapy.International journal of nanomedicine · 2026
    Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Bengt FadeelInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Lucian FarcalDouglas Connect GmbH, Basel, Switzerland.ORCID http://orcid.org/0000-0001-5773-2024
Barry HardyDouglas Connect GmbH, Basel, Switzerland.
Socorro Vázquez-CamposDepartment of New Technologies, LEITAT, Barcelona, Spain.
Danail HristozovDepartment of Biology, University of Venice Ca Foscari, Venice, Italy.
Antonio MarcominiDepartment of Biology, University of Venice Ca Foscari, Venice, Italy.
Iseult LynchSchool of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
Eugenia Valsami-JonesSchool of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-8850-7556
Harri AleniusInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kai SavolainenFinnish Institute of Occupational Health, Helsinki, Finland. Kai.Savolainen@ttl.fi.
Ca' Foscari University of Venice · ITEdelweiss Connect (Switzerland) · CHUniversity of Birmingham · GBFinnish Institute of Occupational Health · FIKarolinska Institutet · SELeitat Technological Center · ESUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Engineered nanomaterials (ENMs) have tremendous potential to produce beneficial technological impact in numerous sectors in society. Safety assessment is, of course, of paramount importance. However, the myriad variations of ENM properties makes the identification of specific features driving toxicity challenging. At the same time, reducing animal tests by introducing alternative and/or predictive in vitro and in silico methods has become a priority. It is important to embrace these new advances in the safety assessment of ENMs. Indeed, remarkable progress has been made in recent years with respect to mechanism-based hazard assessment of ENMs, including systems biology approaches as well as high-throughput screening platforms, and new tools are also emerging in risk assessment and risk management for humans and the environment across the whole life-cycle of nano-enabled products. Here, we highlight some of the key advances in the hazard and risk assessment of ENMs.

Indexed as

AnimalsEnvironmentHigh-Throughput Screening AssaysHumansInformation DisseminationInternetNanostructuresRisk AssessmentSoftwareSystems BiologyToxicity Tests

Identifiers

PMID29980781
OpenAlexW2809776129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.