ArticleScientific reports2018
Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Non-vectorial integration of intersectional short-pulse stimulation enables enhanced deep brain modulation and effective seizure control.Communications medicine · 2026Article
- Temporal differential effects of post-injury alcohol consumption in a mouse model of blast-induced traumatic brain injury.Neuroscience · 2024Article
- Modelling collateral flow and thrombus permeability during acute ischaemic stroke.Journal of the Royal Society, Interface · 2022Article
- Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms.Scientific reports · 2022Article
- On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation.Annals of biomedical engineering · 2021Article
- Psychosocial impairment following mild blast-induced traumatic brain injury in rats.Behavioural brain research · 2021Article
- Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: implication of acrolein and TRPA1.Translational neurodegeneration · 2021Article
- A porous circulation model of the human brain forInterface focus · 2021Article
- A Machine Learning Enhanced Mechanistic Simulation Framework for Functional Deficit Prediction in TBI.Frontiers in bioengineering and biotechnology · 2021Article
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- Ferroptosis-relevant mechanisms and biomarkers for therapeutic interventions in traumatic brain injury.Histology and histopathology · 2020Review
- Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration.Molecular and cellular neurosciences · 2019Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue damage eventually cascading into cognitive deficits, we performed a study on the mechanics of rat brain under blast conditions. To this end, experiments were carried out to analyse and correlate post-injury oxidative stress distribution with cognitive deficits on a live rat exposed to blast. A computational model of the rat head was developed from imaging data and validated against in vivo brain displacement measurements. The blast event was reconstructed in silico to provide mechanistic thresholds that best correlate with cognitive damage at the regional neuronal tissue level, irrespectively of the shape or size of the brain tissue types. This approach was leveraged on a human head model where the prediction of cognitive deficits was shown to correlate with literature findings. The mechanistic insights from this work were finally used to propose a novel protective device design roadmap and potential avenues for therapeutic innovations against blast traumatic brain injury.
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