ArticleScientific reports2018
Sound abnormally stimulates the vestibular system in canal dehiscence syndrome by generating pathological fluid-mechanical waves.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant.The New England journal of medicine · 2021Trial
- Article
- Observational
- The neural basis of vestibular evoked myogenic potentials. The cVEMP is a specific indicator of saccular function.Frontiers in neurology · 2025Review
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- Article
- Skull Vibration-Induced Nystagmus in Superior Semicircular Canal Dehiscence: A New Insight into Vestibular Exploration-A Review.Audiology research · 2024Review
- A Review of Neural Data and Modelling to Explain How a Semicircular Canal Dehiscence (SCD) Causes Enhanced VEMPs, Skull Vibration Induced Nystagmus (SVIN), and the Tullio Phenomenon.Audiology research · 2023Review
- Cochlear Aqueduct Morphology in Superior Canal Dehiscence Syndrome.Audiology research · 2023Article
- A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.Frontiers in integrative neuroscience · 2023Article
- A bone-conducted Tullio phenomenon-A bridge to understand skull vibration induced nystagmus in superior canal dehiscence.Frontiers in neurology · 2023Article
- A Single Fast Test for Semicircular Canal Dehiscence-oVEMP n10 to 4000 Hz-Depends on Stimulus Rise Time.Audiology research · 2022Article
- Differential Activation of Canal and Otolith Afferents by Acoustic Tone Bursts in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Case Report: Fremitus Nystagmus in Superior Canal Dehiscence Syndrome.Frontiers in neurology · 2022Article
- Investigating Performance of cVEMP and oVEMP in the Identification of Superior Canal Dehiscence in Relation to Dehiscence Location and Size.Audiology research · 2021Article
- Rare Disorders of the Vestibular Labyrinth: of Zebras, Chameleons and Wolves in Sheep's Clothing.Laryngo- rhino- otologie · 2021Review
- Similarities and Differences Between Vestibular and Cochlear Systems - A Review of Clinical and Physiological Evidence.Frontiers in neuroscience · 2021Review
- Case Report: Could Hennebert's Sign Be Evoked Despite Global Vestibular Impairment on Video Head Impulse Test? Considerations Upon Pathomechanisms Underlying Pressure-Induced Nystagmus due to Labyrinthine Fistula.Frontiers in neurology · 2021Article
- Biomechanics of Third Window Syndrome.Frontiers in neurology · 2020Review
- Bone-Conducted oVEMP Latency Delays Assist in the Differential Diagnosis of Large Air-Conducted oVEMP Amplitudes.Frontiers in neurology · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Individuals suffering from Tullio phenomena experience dizziness, vertigo, and reflexive eye movements (nystagmus) when exposed to seemingly benign acoustic stimuli. The most common cause is a defect in the bone enclosing the vestibular semicircular canals of the inner ear. Surgical repair often corrects the problem, but the precise mechanisms underlying Tullio phenomenon are not known. In the present work we quantified the phenomenon in an animal model of the condition by recording fluid motion in the semicircular canals and neural activity evoked by auditory-frequency stimulation. Results demonstrate short-latency phase-locked afferent neural responses, slowly developing sustained changes in neural discharge rate, and nonlinear fluid pumping in the affected semicircular canal. Experimental data compare favorably to predictions of a nonlinear computational model. Results identify the biophysical origin of Tullio phenomenon in pathological sound-evoked fluid-mechanical waves in the inner ear. Sound energy entering the inner ear at the oval window excites fluid motion at the location of the defect, giving rise to traveling waves that subsequently excite mechano-electrical transduction in the vestibular sensory organs by vibration and nonlinear fluid pumping.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.