ArticleTranslational psychiatry2018
Altered cerebellar-insular-parietal-cingular subnetwork in adolescents in the earliest stages of anorexia nervosa: a network-based statistic analysis.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01882023 (Comparing Neural Responses to Explicit and Subliminal Food Images in EDNOS Patients and Healthy Controls Using fMRI), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Neural Responses to Explicit and Subliminal Food Images in EDNOS Patients and Healthy Controls Using fMRI
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Brain networks in eating disorders: a systematic review of graph theory studies.Eating and weight disorders : EWD · 2022Pooled it
- The role of prenatal and perinatal factors in eating disorders: a systematic review.Archives of women's mental health · 2021Pooled it
- Brain Connectivity and Machine Learning Approaches to assess the underlying neurobiology and prediction accuracy of anorexia nervosa: A replication study.Psychiatry research. Neuroimaging · 2026Article
- Shared and disorder-specific resting-state neural activity characteristics in patients with anorexia nervosa and bulimia nervosa.Journal of eating disorders · 2026Article
- Sex difference in neural substrates linking negative body image and disordered eating behaviors.Brain structure & function · 2025Article
- Dynamic Functional Connectivity Markers in Anorexia Nervosa and Their Association With Clinical Symptoms: A Cross-Sectional Study.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Avoidant/restrictive food intake disorder-like syndrome and cerebellar tumor in an adolescent: a case report.Journal of eating disorders · 2025Article
- Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa.NeuroImage. Clinical · 2025Article
- Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa.Translational psychiatry · 2023Article
- Article
- Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Neuroimaging Findings in Adolescents and Young Adults with Anorexia Nervosa: A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Cortical thinning and associated connectivity changes in patients with anorexia nervosa.Translational psychiatry · 2021Article
- Differences in Brain Functional Networks of Executive Function Between Cantonese-Mandarin Bilinguals and Mandarin Monolinguals.Frontiers in human neuroscience · 2021Article
- Within-network brain connectivity in Crohn's disease patients with gadolinium deposition in the cerebellum.Neuroradiology · 2020Article
- Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2020Article
- The promise of neurobiological research in anorexia nervosa.Current opinion in psychiatry · 2019Review
- Functional Connectivity Patterns and the Role of 5-HTTLPR Polymorphism on Network Architecture in Female Patients With Anorexia Nervosa.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, few functional magnetic resonance imaging (fMRI) studies have explored resting-state functional connectivity (RSFC) in long-lasting anorexia nervosa (AN) patients via graph analysis. The aim of the present study is to investigate, via a graph approach (i.e., the network-based statistic), RSFC in a sample of adolescents at the earliest stages of AN (i.e., AN duration less than 6 months). Resting-state fMRI data was obtained from 15 treatment-naive female adolescents with AN restrictive type (AN-r) in its earliest stages and 15 age-matched healthy female controls. A network-based statistic analysis was used to isolate networks of interconnected nodes that differ between the two groups. Group comparison showed a decreased connectivity in a sub-network of connections encompassing the left and right rostral ACC, left paracentral lobule, left cerebellum (10th sub-division), left posterior insula, left medial fronto-orbital gyrus, and right superior occipital gyrus in AN patients. Results were not associated to alterations in intranodal or global connectivity. No sub-networks with an increased connectivity were identified in AN patients. Our findings suggest that RSFC may be specifically affected at the earliest stages of AN. Considering that the altered sub-network comprises areas mainly involved in somatosensory and interoceptive information and processing and in emotional processes, it could sustain abnormal integration of somatosensory and homeostatic signals, which may explain body image disturbances in AN. Further studies with larger samples and longitudinal designs are needed to confirm our findings and better understand the role and consequences of such functional alterations in AN.
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