ArticleNature communications2018
Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
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- Uncovering a new family of conserved virulence factors that promote the production of host-damaging outer membrane vesicles in gram-negative bacteria.Journal of extracellular vesicles · 2025Article
- Secondary messenger signalling influences Pseudomonas aeruginosa adaptation to sinus and lung environments.The ISME journal · 2024Article
- Multilocus sequence typing and antibiotic resistance of Aeromonas isolated from freshwater fish in Hebei Province.PloS one · 2024Article
- Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogenMicrobiology (Reading, England) · 2023Article
- Genetic and environmental determinants of surface adaptations inMicrobiology (Reading, England) · 2023Article
- Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance.JCI insight · 2022Article
- RclS Sensor Kinase Modulates Virulence ofInternational journal of molecular sciences · 2022Article
- Persisting uropathogenic Escherichia coli lineages show signatures of niche-specific within-host adaptation mediated by mobile genetic elements.Cell host & microbe · 2022Article
- Article
- Inter-species interactions alter antibiotic efficacy in bacterial communities.The ISME journal · 2022Article
- A prediction and interpretation machine learning framework of mortality risk among severe infection patients with pseudomonas aeruginosa.Frontiers in medicine · 2022Article
- Antibiotic Resistance in Pseudomonas.Advances in experimental medicine and biology · 2022Article
- Development of liquid culture media mimicking the conditions of sinuses and lungs in cystic fibrosis and health.F1000Research · 2022Article
- From genotype to phenotype: adaptations ofMicrobial genomics · 2021Review
- Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.PLoS pathogens · 2021Article
- Transmission, adaptation and geographical spread of theMicrobial genomics · 2021Article
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Authors and funding
16 authors at 3 institutions in 3 countries.
Funding
Abstract
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved P. aeruginosa in a murine model of respiratory tract infection and observed early-acquired mutations in pmrB, encoding the sensor kinase of a two-component system that promoted establishment and persistence of infection. Here, using proteomics, we show downregulation of proteins involved in LPS biosynthesis, antimicrobial resistance and phenazine production in pmrB mutants, and upregulation of proteins involved in adherence, lysozyme resistance and inhibition of the chloride ion channel CFTR, relative to wild-type strain LESB65. Accordingly, pmrB mutants are susceptible to antibiotic treatment but show enhanced adherence to airway epithelial cells, resistance to lysozyme treatment, and downregulate host CFTR expression. We propose that P. aeruginosa pmrB mutations in CF patients are subject to an evolutionary trade-off, leading to enhanced colonisation potential, CFTR inhibition, and resistance to host defences, but also to increased susceptibility to antibiotics.
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