Evidence map›Paper›PMID 29980657›Full record

ArticleMolecular pharmacology2018

Molecular Determinants of the Differential Modulation of Ca

Yuchen Wang, Shiqi Tang, Kyle E Harvey, Amy E Salyer, T August Li, Emily K Rantz, Markus A Lill, Gregory H Hockerman

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. The L-type calcium channel CaV1.3: A potential target for cancer therapy.Journal of cellular and molecular medicine · 2024
    Review
  3. Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Review
  6. CaBritish journal of pharmacology · 2023
    Review
  7. CACNA1C (CaNeuropharmacology · 2022
    Review
  8. Article
  9. A Sea AnemoneToxins · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Anti-schistosomal action of the calcium channel agonist FPL-64176.International journal for parasitology. Drugs and drug resistance · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuchen WangDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Shiqi TangDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Kyle E HarveyDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Amy E SalyerDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
T August LiDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Emily K RantzDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Markus A LillDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana.
Gregory H HockermanDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University College of Pharmacy, West Lafayette, Indiana gregh@purdue.edu.
Purdue University West Lafayette · US

Funding

Differential Modulation of Cav1.2 and Cav1.3R21NS101535 · NINDS · PURDUE UNIVERSITY · PI HOCKERMAN, GREGORY HOWARD · 2017 to 2018
$409k
NINDS NIH HHS R21 NS101535
6 · The paper itself

Abstract

Nifedipine and FPL 64176 (FPL), which block and potentiate L-type voltage-gated Ca

Indexed as

Amino Acid SequenceCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypeDose-Response Relationship, DrugHEK293 CellsHumansNifedipineProtein Structure, SecondaryPyrrolesCACNA1C protein, humanCACNA1D protein, humanCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypeFPL 64176NifedipinePyrroles

Identifiers

PMID29980657
PMCPMC11033928
OpenAlexW2825606663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.