Evidence map›Paper›PMID 29980639›Full record

ArticleNeurology2018

Leukoaraiosis is independently associated with naming outcome in poststroke aphasia.

Amy Wright, Donna Tippett, Sadhvi Saxena, Rajani Sebastian, Bonnie Breining, Andreia Faria, Argye E Hillis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. White Matter Hyperintensities as a Predictor of Aphasia Recovery.Archives of physical medicine and rehabilitation · 2024
    Trial
  3. Trial
  4. Article
  5. Accelerated brain aging and anterior white matter hyperintensity burden in chronic post-stroke aphasia: a lesion-aware MRI analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Insights gained over 60 years on factors shaping post-stroke aphasia recovery: A commentary on Vignolo (1964).Cortex; a journal devoted to the study of the nervous system and behavior · 2024
    Article
  15. Longitudinal Progression of White Matter Hyperintensity Severity in Chronic Stroke Aphasia.Archives of rehabilitation research and clinical translation · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amy WrightFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Donna TippettFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Sadhvi SaxenaFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Rajani SebastianFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Bonnie BreiningFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Andreia FariaFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD.
Argye E HillisFrom the Departments of Neurology (A.W., D.T., S.S., R.S., B.B., A.E.H.), Physical Medicine & Rehabilitation (D.T., A.E.H.), Otolaryngology and Head & Neck Surgery (D.T.), and Radiology (A.F.), Johns Hopkins University School of Medicine; and Department of Cognitive Science (A.E.H.), Johns Hopkins University, Baltimore, MD. argye@jhmi.edu.
Johns Hopkins University · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HICKOK, GREGORY · 2016 to 2025
$25.0M
Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
The Neural Basis of Impaired Affective Prosody in Alzheimer's Disease and Frontotemporal DegenerationR01DC015466 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2017 to 2021
$3.5M
NIDCD NIH HHS P50 DC014664NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC015466
6 · The paper itself

Abstract

objectiveTo test the hypothesis that severity of leukoaraiosis in the noninfarcted hemisphere at onset is associated with poorer language outcome after poststroke aphasia independently of volume of infarct, damage to 3 critical language areas (left inferior frontal gyrus, superior longitudinal fasciculus, and superior temporal gyrus), comorbid conditions, and time since stroke.

methodsIn this cross-sectional study, we evaluated naming outcome (>3 months after stroke) in 42 individuals who initially had aphasia after stroke. We rated leukoaraiosis in the right hemisphere 1 to 4 weeks from onset of stroke using the Cardiovascular Health Study rating scale. We evaluated associations between severity of leukoaraiosis and each measure of naming using Spearman correlations and evaluated the independent contributions of leukoaraiosis, lesion volume, months since onset, comorbid conditions, and damage to critical nodes of the language network on language outcomes using logistic regression. We also evaluated associations between dichotomously defined leukoaraiosis and language outcomes using χ

resultsSeverity of leukoaraiosis at onset correlated with object naming (ρ = -0.56,

conclusionNaming outcome after poststroke aphasia is influenced by the initial severity of right hemisphere leukoaraiosis independently of other variables. Degree of recovery from aphasia may depend on the integrity of the noninfarcted brain tissue.

Indexed as

AdultAgedAphasiaCross-Sectional StudiesFemaleHumansLanguage TestsLeukoaraiosisMaleMiddle AgedStroke

Identifiers

PMID29980639
PMCPMC6105047
OpenAlexW2821652326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.