Evidence map›Paper›PMID 29980634›Full record

ArticleThe Journal of general physiology2018

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin.

Pradeep Kota, Martina Gentzsch, Yan L Dang, Richard C Boucher, M Jackson Stutts

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Epithelial NaComprehensive Physiology · 2024
    Review
  2. Review
  3. Review
  4. SARS-CoV-2 furin cleavage site was not engineered.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  5. Review
  6. Review
  7. A call for an independent inquiry into the origin of the SARS-CoV-2 virus.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Osmotic Adaptation by NaBiomedicines · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pradeep KotaMarsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-2825-5123
Martina GentzschMarsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-9435-0321
Yan L DangMarsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-8986-7406
Richard C BoucherMarsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC.
M Jackson StuttsMarsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, NC jack_stutts@med.unc.edu.ORCID 0000-0002-3159-7802
University of North Carolina at Chapel Hill · US

Funding

Purinergic Control of CFTR-ENaC Interactions in Alveolar EpitheliaP01HL110873 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2016
$10.7M
NHLBI NIH HHS P01 HL110873
6 · The paper itself

Abstract

Epithelial Na

Indexed as

AnimalsEpithelial Sodium ChannelsFemaleFurinOocytesXenopusEpithelial Sodium ChannelsFurin

Identifiers

PMID29980634
PMCPMC6080898
OpenAlexW2811933959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.