Evidence map›Paper›PMID 29980614›Full record

ArticleMolecular systems biology2018

Thermal proteome profiling in bacteria: probing protein state

André Mateus, Jacob Bobonis, Nils Kurzawa, Frank Stein, Dominic Helm, Johannes Hevler, Athanasios Typas, Mikhail M Savitski

Abstract read
In one paragraph

Article in Molecular systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Proteome-wide analysis of protein stability in Escherichia coli under acid stress.Journal of industrial microbiology & biotechnology · 2026
    Article
  11. Methods for the Investigation of Protein-Ligands Interactions.Advances in experimental medicine and biology · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

André MateusGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-6870-0677
Jacob BobonisGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Nils KurzawaGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-7846-2817
Frank SteinProteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
Dominic HelmProteomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
Johannes HevlerGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Athanasios TypasGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany typas@embl.de mikhail.savitski@embl.de.ORCID 0000-0002-0797-9018
Mikhail M SavitskiGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany typas@embl.de mikhail.savitski@embl.de.ORCID 0000-0003-2011-9247

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing antibiotic resistance urges for new technologies for studying microbes and antimicrobial mechanism of action. We adapted thermal proteome profiling (TPP) to probe the thermostability of

Indexed as

Cell MembraneCytoplasmEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGene Expression Regulation, DevelopmentalProtein StabilityProteomicsThermodynamicsTransition TemperatureEscherichia coli ProteinsEscherichia colimetabolic pathwaysprotein complexestarget engagementthermal proteome profiling

Identifiers

PMID29980614
PMCPMC6056769

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.