Evidence map›Paper›PMID 29980599›Full record

ArticleThe Journal of biological chemistry2018

Substrate-induced domain movement in a bifunctional protein, DcpA, regulates cyclic di-GMP turnover: Functional implications of a highly conserved motif.

Binod K Bharati, Raju Mukherjee, Dipankar Chatterji

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Binod K BharatiFrom the Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India and.
Raju MukherjeeDepartment of Biology, Indian Institute of Science Education and Research, Tirupati 517507, India.
Dipankar ChatterjiFrom the Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India and dipankar@iisc.ac.in.
Indian Institute of Science Bangalore · INIndian Institute of Science Education and Research, Tirupati · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In eubacteria, cyclic di-GMP (c-di-GMP) signaling is involved in virulence, persistence, motility and generally orchestrates multicellular behavior in bacterial biofilms. Intracellular c-di-GMP levels are maintained by the opposing activities of diguanylate cyclases (DGCs) and cognate phosphodiesterases (PDEs). The c-di-GMP homeostasis in

Indexed as

Conserved SequenceAmino Acid SequenceBacterial ProteinsCyclic GMPEscherichia coli ProteinsHomeostasisMycobacterium smegmatisPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesProtein BindingProtein ConformationProtein DomainsBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsPhosphoric Diester HydrolasesPhosphorus-Oxygen Lyasesbacterial virulencec-di-GMP turnovercyclic di-GMP (c-di-GMP)DcpAdiguanylate cyclasedomain movementfluorescence anisotropyfluorescence resonance energy transfer (FRET)Förster's distancephosphodiesterasesecond messenger

Identifiers

PMID29980599
PMCPMC6130938
OpenAlexW2878893122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.