ArticleMalaria journal2018
Haemolysis and haem oxygenase-1 induction during persistent "asymptomatic" malaria infection in Burkinabé children.
Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Interleukin-10 limits immune-mediated pathology in chronic subclinical plasmodial infection.PLoS neglected tropical diseases · 2025Article
- Neutrophils versus Protozoan Parasites:Microorganisms · 2024Review
- Dry season prevalence of Plasmodium falciparum in asymptomatic gambian children, with a comparative evaluation of diagnostic methods.Malaria journal · 2022Article
- Deferiprone-Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent inBioinorganic chemistry and applications · 2022Article
- Neutrophils in malaria: A double-edged sword role.Frontiers in immunology · 2022Review
- 'Bouncing Back' From Subclinical Malaria: Inflammation and Erythrocytosis After Resolution ofFrontiers in immunology · 2022Article
- Hemozoin: a Complex Molecule with Complex Activities.Current clinical microbiology reports · 2021Article
- New insights into the role of heme oxygenase-1 in acute kidney injury.Kidney research and clinical practice · 2020Review
- Article
- Malaria, anemia, and invasive bacterial disease: A neutrophil problem?Journal of leukocyte biology · 2019Review
- Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria.Malaria journal · 2019Article
- Functional antibodies againstWellcome open research · 2018Article
- Neutrophils and Malaria.Frontiers in immunology · 2018Review
- Subclinical malaria among pregnant women living in refugee settlements in Northern Uganda.Therapeutic advances in infectious diseaseArticle
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase susceptibility to invasive bacterial disease. However, the majority of community-associated malaria infections are subclinical, often termed "asymptomatic" and the consequences of low-grade haemolysis during subclinical malaria infection are unknown. STUDY DESIGN AND
resultsAs part of an ongoing study of subclinical malaria in Burkina Faso, 23 children with subclinical Plasmodium falciparum infections (determined by qPCR) were compared with 21 village-matched uninfected control children. Infected children showed evidence of persistent haemolysis over 35 days, with raised plasma haem and HO-1 concentrations. Concentrations of IL-10, which can also directly activate HO-1, were also higher in infected children compared to uninfected children. Regression analysis revealed that HO-1 was associated with haemolysis, but not with parasite density, anaemia or IL-10 concentration.
conclusionsThis study reveals that subclinical P. falciparum malaria infection is associated with sustained haemolysis and the induction of HO-1. Given the association between HO-1, neutrophil dysfunction and increased risk of Salmonella bacteraemia, prolonged HO-1 induction may explain epidemiological associations and geographic overlap between malaria and invasive bacterial disease. Further studies are needed to understand the consequences of persistent subclinical malaria infection, low-grade haemolysis and raised HO-1 on immune cell function and risk of comorbidities.
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