ArticleBiomaterials2018
Fabrication of injectable and superelastic nanofiber rectangle matrices ("peanuts") and their potential applications in hemostasis.
Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- 3D hierarchically aligned nanofiber scaffolds promote cell migration for tissue regeneration.Nature protocols · 2026Review
- Nanofibrous Platforms for Advanced Wound Therapeutics: Mechanisms, Materials, and Clinical Horizons.Macromolecular bioscience · 2026Review
- Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs.Nature communications · 2026Article
- Article
- Aligned nanofiber-based responsive sponge scaffolds for peripheral nerve regeneration.Journal of nanobiotechnology · 2025Article
- Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.Nature communications · 2025Article
- Evaluating the impact of clinical and translational pilot funding using multiple outcome metrics.Journal of clinical and translational science · 2025Article
- Injectable and rapidly expandable thrombin-decorated cryogels achieve rapid hemostasis and high survival rates in a swine model of lethal junctional hemorrhage.Bioactive materials · 2024Article
- Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs.Nature communications · 2024Article
- A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage.Materials today. Bio · 2024Article
- New dimensions of electrospun nanofiber material designs for biotechnological uses.Trends in biotechnology · 2024Review
- Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma-Induced Bleeding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Hierarchically Assembled Nanofiber Scaffolds with Dual Growth Factor Gradients Promote Skin Wound Healing Through Rapid Cell Recruitment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Fabricating the multibranch carboxyl-modified cellulose for hemorrhage control.Materials today. Bio · 2024Article
- Enhanced Hemostatic and Procoagulant Efficacy of PEG/ZnO Hydrogels: A Novel Approach in Traumatic Hemorrhage Management.Gels (Basel, Switzerland) · 2024Article
- Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material.Bioengineering (Basel, Switzerland) · 2023Article
- Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis.Molecules (Basel, Switzerland) · 2023Review
- Super-Elastic Carbonized Mushroom Aerogel for Management of Uncontrolled Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Nanofiber Aerogels with Precision Macrochannels and LL-37-Mimic Peptides Synergistically Promote Diabetic Wound Healing.Advanced functional materials · 2023Article
- Multifunctional 3D platforms for rapid hemostasis and wound healing: Structural and functional prospects at biointerfaces.International journal of bioprinting · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix ("peanut") fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples. These nanofiber peanuts are capable of being packed into a syringe for injection. Further in vivo tests indicated the effectiveness of nanofiber peanuts for hemostasis in a porcine liver injury model. This new class of nanofiber-based materials may hold great promise for hemostatic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.