Evidence map›Paper›PMID 29979961›Full record

ArticleMolecular cell2018

A First Glimpse of Nucleation of Phase Transitions in Living Cells.

Ammon E Posey, Rohit V Pappu

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Small heat shock proteins and biomolecular condensates.Cellular and molecular life sciences : CMLS · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ammon E PoseyDepartment of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Rohit V PappuDepartment of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: pappu@wustl.edu.

Funding

ROLE OF CHAIN LENGTH AND SEQUENCE CONTEXTS ON POLYGLUTAMINE OLIGOMERIZATIONR01NS056114 · NINDS · WASHINGTON UNIVERSITY · PI PAPPU, ROHIT V · 2007 to 2020
$4.4M
Mechanism of modulation of huntingtin exon 1 aggregation by profilinR01NS089932 · NINDS · WASHINGTON UNIVERSITY · PI DIAMOND, MARC I, LANGEN, RALF · 2016 to 2020
$2.8M
NINDS NIH HHS R01 NS056114NINDS NIH HHS R01 NS089932
6 · The paper itself

Abstract

Prion formation and propagation involve the nucleation and growth of protein-based supramolecular assemblies. In this issue of Molecular Cell, Khan et al. (2018) report novel methods that enable quantitative, high-throughput analyses of nucleation of supramolecular assemblies by prion-forming proteins in living cells. Their approaches turn living cells into veritable test tubes for biophysical investigations.

Indexed as

PrionsCell Physiological PhenomenaPrions

Identifiers

PMID29979961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.