ArticlePloS one2018
Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Renal Function in Patients after Metabolic and Bariatric Surgery.Obesity surgery · 2025Article
- Article
- Beyond linearity: a threshold effect links serum creatinine to SIRI in osteoporotic fractures.Frontiers in medicine · 2025Article
- Relationship between Plasma and Saliva Urea Nitrogen Concentrations in New Zealand Red Deer Calves (Animals : an open access journal from MDPI · 2024Article
- Extracellular DNA concentrations in various aetiologies of acute kidney injury.Scientific reports · 2022Article
- Dynamics of salivary markers of kidney functions in acute and chronic kidney diseases.Scientific reports · 2020Article
- Behavioral Changes During Development of Chronic Kidney Disease in Rats.Frontiers in medicine · 2019Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma creatinine and urea are commonly used markers of kidney function in both acute and chronic renal failure. The needed repeated blood collection is associated with pain, stress and might lead to infections. Saliva has the potential to be a non-invasive alternative diagnostic fluid. The use of saliva in clinical practice is limited, since many factors affect the concentration of salivary biomarkers. The aim of our study was to analyze salivary creatinine and urea in the animal models of acute and chronic renal disease. Bilateral nephrectomy and adenine nephropathy were induced in adult male mice. Both, plasma creatinine and urea were higher in animals with renal failure compared to controls. Salivary creatinine was higher by 81% and salivary urea by 43% in comparison to the control group, but only in animals with bilateral nephrectomy and not in adenine nephropathy. Our results indicate that the increase of salivary creatinine and urea depends on the experimental model of renal failure and its severity. Further studies are needed to monitor the dynamics of salivary markers of renal function and to reveal determinants of their variability.
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Registered trials
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