Evidence map›Paper›PMID 29979584›Full record

ArticleEnvironmental science & technology2018

Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.

Thomas H Hampton, Craig Jackson, Dawoon Jung, Celia Y Chen, Stephen P Glaholt, Bruce A Stanton, John K Colbourne, Joseph R Shaw

Abstract read
In one paragraph

Article in Environmental science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thomas H HamptonEnvironmental Genomics Group, School of Biosciences , University of Birmingham , Birmingham , United Kingdom.ORCID 0000-0003-0543-402X
Craig JacksonThe School of Public and Environmental Affairs , Indiana University , Bloomington , Indiana 47405 , United States.
Dawoon JungDepartment of Microbiology and Immunology , Geisel School of Medicine at Dartmouth , Hanover , New Hampshire 03755 , United States.
Celia Y ChenDepartment of Biological Sciences , Dartmouth College , Hanover , New Hampshire 03755 , United States.
Stephen P GlaholtThe School of Public and Environmental Affairs , Indiana University , Bloomington , Indiana 47405 , United States.
Bruce A StantonDepartment of Microbiology and Immunology , Geisel School of Medicine at Dartmouth , Hanover , New Hampshire 03755 , United States.
John K ColbourneEnvironmental Genomics Group, School of Biosciences , University of Birmingham , Birmingham , United Kingdom.
Joseph R ShawEnvironmental Genomics Group, School of Biosciences , University of Birmingham , Birmingham , United Kingdom.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
VARIATION IN BIOACCUMULATION AND BIOMAGNIFICATION OF METALS IN NORTHERN US LAKESP42ES007373 · NIEHS · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 1995 to 2019
$52.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Effects of environmental contamination on gene copy number variation: Molecular bR01ES019324 · NIEHS · TRUSTEES OF INDIANA UNIVERSITY · PI SHAW, JOSEPH R. · 2010 to 2014
$2.2M
NIEHS NIH HHS P42 ES007373NIEHS NIH HHS R01 ES019324NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

Toxicogenomic approaches can detect and classify adverse interactions between environmental toxicants and other environmental stressors but require more complex experimental designs and analytical approaches. Here we use novel toxicogenomic techniques to analyze the effect of arsenic exposure in wild killifish populations acclimating to changing salinity. Fish from three populations were acclimated to full strength seawater and transferred to fresh water for 1 or 24 h. Linear models of gene expression in gill tissue identified 31 genes that responded to osmotic shock at 1 h and 178 genes that responded at 24 h. Arsenic exposure (100 μg/L) diminished the responses (reaction norms) of these genes by 22% at 1 h ( p = 1.0 × 10

Indexed as

ArsenicFundulidaeAcclimatizationAnimalsGene ExpressionGillsMiceSalinitySeawaterArsenic

Identifiers

PMID29979584
PMCPMC6084426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.