ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018
Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Exploring Carbamazepine Polymorph Crystal Growth in Water by Enhanced Sampling Simulations.ACS omega · 2024Article
- Monitoring Polymorphic Phase Transitions in Flufenamic Acid Amorphous Solid Dispersions Using Hyphenated X-ray Diffraction-Differential Scanning Calorimetry.Molecular pharmaceutics · 2022Article
- Mechanistic In Situ and Ex Situ Studies of Phase Transformations in Molecular Co-Crystals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Temperature-induced phase transitions in carbamazepine (CBZ) and 10,11-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry-X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.
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Registered trials
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