ArticleJournal of synchrotron radiation2018
Smaller capillaries improve the small-angle X-ray scattering signal and sample consumption for biomacromolecular solutions.
Article in Journal of synchrotron radiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Using in-situ small-angle scattering to reveal the structure and dynamics of supramolecular polymers.Nature communications · 2025Review
- Compact polyethylenimine-complexed mRNA vaccines.Nature nanotechnology · 2025Article
- A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells.Nature communications · 2025Article
- Using NMR diffusion data to validate MD models of disordered proteins: Test case of N-terminal tail of histone H4.Biophysical journal · 2024Article
- BioSAXS at European Synchrotron Radiation Facility - Extremely Brilliant Source: BM29 with an upgraded source, detector, robot, sample environment, data collection and analysis software.Journal of synchrotron radiation · 2023Article
- Contrast variation SAXS: Sample preparation protocols, experimental procedures, and data analysis.Methods in enzymology · 2022Article
- ASAXS measurements on ferritin and apoferritin at the bioSAXS beamline P12 (PETRA III, DESY).Journal of applied crystallography · 2021Article
- Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis.Nature communications · 2021Article
- Anomalous SAXS at P12 beamline EMBL Hamburg: instrumentation and applications.Journal of synchrotron radiation · 2021Article
- µDrop: a system for high-throughput small-angle X-ray scattering measurements of microlitre samples.Journal of applied crystallography · 2021Article
- Solution scattering at the Life Science X-ray Scattering (LiX) beamline.Journal of synchrotron radiation · 2020Article
- Dynamics of soft nanoparticle suspensions at hard X-ray FEL sources below the radiation-damage threshold.IUCrJ · 2018Article
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8 authors.
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Abstract
Radiation damage by intense X-ray beams at modern synchrotron facilities is one of the major complications for biological small-angle X-ray scattering (SAXS) investigations of macromolecules in solution. To limit the damage, samples are typically measured under a laminar flow through a cell (typically a capillary) such that fresh solution is continuously exposed to the beam during measurement. The diameter of the capillary that optimizes the scattering-to-absorption ratio at a given X-ray wavelength can be calculated a priori based on fundamental physical properties. However, these well established scattering and absorption principles do not take into account the radiation susceptibility of the sample or the often very limited amounts of precious biological material available for an experiment. Here it is shown that, for biological solution SAXS, capillaries with smaller diameters than those calculated from simple scattering/absorption criteria allow for a better utilization of the available volumes of radiation-sensitive samples. This is demonstrated by comparing two capillary diameters d
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