Evidence map›Paper›PMID 29979130›Full record

ArticleJournal of neurosurgery. Pediatrics2018

Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution's experience.

Ryan M Naylor, Anton Wohl, Aditya Raghunathan, Laurence J Eckel, Gesina F Keating, David J Daniels

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurosurgery. Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Desmoplastic infantile ganglioglioma and astrocytoma: A narrative review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Mixed Solid and Cystic Mass in an Infant.AJNR. American journal of neuroradiology · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ryan M Naylor1Mayo Medical School.
Anton WohlDepartments of4Neurologic Surgery.
Aditya Raghunathan5Laboratory Medicine and Pathology.
Laurence J Eckel6Radiology, and.
Gesina F Keating7Neurology, Mayo Clinic, Rochester, Minnesota.
David J DanielsDepartments of4Neurologic Surgery.
Mayo Clinic · USMayo Clinic in Arizona · USUniversity Radiology · US

Funding

Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
The Role of Nup88 Overexpression in Cellular Transformation and TumorigenesisF30CA189339 · NCI · MAYO CLINIC ROCHESTER · PI NAYLOR, RYAN M · 2014 to 2017
$165k
NCI NIH HHS F30 CA189339NIGMS NIH HHS T32 GM065841
6 · The paper itself

Abstract

objectiveThe aim of this study was to describe the clinical presentation, imaging appearance, and differential outcomes based on tumor location in 7 patients with desmoplastic infantile astrocytoma and desmoplastic infantile gangliogliomas (DIA/DIG).

methodsData of 7 patients with histopathology-proven DIA/DIGs and preoperative imaging were retrospectively reviewed, and age, sex, clinical presentation, imaging characteristics, tumor location, surgical procedure, postoperative morbidity, and overall mortality were recorded.

resultsTwo subgroups of patients with DIA/DIGs were found to exist based on whether their tumor was located in the cerebral hemispheres or suprasellar region. Nearly all patients presented with rapidly enlarging head circumference regardless of tumor location. However, ocular abnormalities, including nystagmus and preference for downward gaze, were specific for patients with suprasellar disease. These patients experienced significant postoperative complications and had poor long-term outcomes. In contrast, patients with hemispheric tumors underwent more extensive resection than patients with suprasellar tumors, had uneventful postoperative courses, and had no documented long-term comorbidities.

conclusionsPostoperative course and long-term outcome for patients with DIA/DIGs were correlated to the anatomical location and radiographic appearance of their tumor at presentation, despite having histologically and molecularly indistinguishable, WHO grade I tumors.

Indexed as

AstrocytomaBrain NeoplasmsCarcinoma, Small CellFemaleGangliogliomaHumansInfantMaleRetrospective Studiesdesmoplastic infantile astrocytomadesmoplastic infantile gangliogliomaDIA = desmoplastic infantile astrocytomaDIG = desmoplastic infantile gangliogliomaneuroradiologyoncologyoutcomespediatric neurosurgery

Identifiers

PMID29979130
PMCPMC6261346
OpenAlexW2815216232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.