Evidence map›Paper›PMID 29978902›Full record

ReviewComprehensive Physiology2018

Interactions of Gut Endocrine Cells with Epithelium and Neurons.

Rodger A Liddle

Abstract readReview
In one paragraph

Review in Comprehensive Physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  3. The enteric nervous system.Physiological reviews · 2023
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rodger A LiddleDepartment of Medicine, Duke University and Durham VA Healthcare System, Durham, North Carolina, USA.
Durham VA Health Care System · US

Funding

Pathogenic Mechanisms of PancreatitisR01DK064213 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2004 to 2017
$4.7M
The role of gut endocrine cells in Parkinson's DiseaseR01DK109368 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2016 to 2019
$1.4M
Receptor Regulation of CCK Cell FunctionR01DK098796 · NIDDK · DUKE UNIVERSITY · PI LIDDLE, RODGER A. · 2013 to 2016
$1.4M
Gut Neuroendocrine Cell Signaling and ObesityI01BX002230 · VA · DURHAM VA MEDICAL CENTER · PI LIDDLE, RODGER A. · 2014 to 2022
–
BLRD VA I01 BX002230NIDDK NIH HHS R01 DK064213NIDDK NIH HHS R01 DK098796NIDDK NIH HHS R01 DK109368
6 · The paper itself

Abstract

Even the simplest animals possess sophisticated systems for sensing and securing nutrients. After all, ensuring adequate nutrition is essential for sustaining life. Once multicellular animals grew too large to be nourished by simple diffusion of nutrients from their environment, they required a digestive system for the absorption and digestion of food. The majority of cells in the digestive tract are enterocytes that are designed to absorb nutrients. However, the digestive tracts of animals ranging from worms to humans contain specialized cells that discriminate between nutrients and nondigestible ingestants. These cells "sense" both the environment within the gut lumen and nutrients as they cross the gut epithelium. This dual sensing is then translated into local signals that regulate the gut epithelium or distant signals through hormones or nerves. This review will discuss how sensors of the gut interact with cells of the epithelium and neurons to regulate epithelial integrity and initiate neural transmission from the gut lumen. © 2017 American Physiological Society. Compr Physiol 8:1019-1030, 2018.

Indexed as

AnimalsEnteroendocrine CellsGastrointestinal TractHumansIntestinal MucosaNeurons

Identifiers

PMID29978902
PMCPMC6487668
OpenAlexW2902726463

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.