Evidence map›Paper›PMID 29978444›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2019

The association of potentially inappropriate medication use on health outcomes and hospital costs in community-dwelling older persons: a longitudinal 12-year study.

Virva Hyttinen, Johanna Jyrkkä, Leena K Saastamoinen, Anna-Kaisa Vartiainen, Hannu Valtonen

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Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  15. Can Land Transfer Alleviate the Poverty of the Elderly? Evidence from Rural China.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Virva HyttinenDepartment of Health and Social Management, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. virva.hyttinen@uef.fi.ORCID http://orcid.org/0000-0003-2022-1065
Johanna JyrkkäAssessment of Pharmacotherapies, Finnish Medicines Agency, Kuopio, Finland.
Leena K SaastamoinenKela Research, The Social Insurance Institution, Helsinki, Finland.
Anna-Kaisa VartiainenDepartment of Health and Social Management, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Hannu ValtonenDepartment of Health and Social Management, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
University of Eastern Finland · FIFinnish Medicines Agency Fimea · FISocial Insurance Institution · FI

Funding

Kela 15/26/2015
6 · The paper itself

Abstract

aimsTo determine (1) whether potentially inappropriate medication (PIM) use defined by the Meds75 + database is associated with fracture-specific hospitalisations and all-cause mortality, and (2) the association between PIM use and all-cause hospitalisation costs in a 12-year follow-up of a nationwide sample of people aged ≥ 65 years in Finland.

methodsThis is a longitudinal study of 20,666 community-dwelling older persons with no prior purchases of PIMs within a 2-year period preceding the index date (1 Jan 2002), who were followed until the end of 2013. Data were obtained from the Finnish Prescription Register, and it was accompanied by information on inpatient care, causes of deaths and socioeconomic status from other national registers. Propensity score matching (PSM) analysis was used to account for potential selection effect in PIM use. Cox proportional hazards regression was used to identify the time to the first fracture or death by comparing PIM-users (n = 10,333) with non-users (n = 10,333). The association between PIM use and hospital costs was analysed with a fixed effects linear model.

resultsPIM use was weakly associated with an increased risk of fractures and death. The association was stronger in the first PIM-use periods. Hospitalised PIM-users had 15% higher hospital costs compared to non-users during the 12-year follow-up.

conclusionPIM initiation was associated with an increased risk of fracture-specific hospitalisation and mortality and PIM-users had higher hospital costs than non-users. Health care providers should carefully consider these issues when prescribing PIM for older persons.

Indexed as

Cause of DeathPotentially Inappropriate Medication ListAccidental FallsAgedAged, 80 and overFemaleFinlandFractures, BoneHospital CostsHumansLongitudinal StudiesMaleMedication ErrorsMortalityProportional Hazards ModelsRegistriesHealth outcomesHospital costsOlder personsPotentially inappropriate medicationsRegister-based study

Identifiers

PMID29978444
OpenAlexW2845433941

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.