Evidence map›Paper›PMID 29978153›Full record

ArticleJournal of the Endocrine Society2018

Differential Effects of Estradiol and Progesterone on Cardiovascular Risk Factors in Postmenopausal Women.

Ferdinand Roelfsema, Rebecca J Yang, Johannes D Veldhuis

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Ferdinand RoelfsemaDepartment of Internal Medicine, Section Endocrinology and Metabolism, Leiden University Medical Center, ZA Leiden, Netherlands.
Rebecca J YangEndocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota.
Johannes D VeldhuisEndocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USLeiden University Medical Center · NL

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 1995 to 2015
$17.0M
Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenR01AG029362 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2007 to 2016
$4.0M
Aging Systems in Geriatrics: the Male Gonadal AxisR01AG031763 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2010 to 2014
$1.9M
Actions of Testosterone on the Aging Male GH AxisR01AG019695 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2012 to 2016
$1.9M
NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR002377NIA NIH HHS R01 AG019695NIA NIH HHS R01 AG029362NIA NIH HHS R01 AG031763NIDDK NIH HHS P30 DK050456
6 · The paper itself

Abstract

contextControlled, blinded studies of sex-hormone replacement in postmenopausal women using natural estradiol (E

objectiveTo delineate the effect of E

designA placebo-controlled, double-masked, prospectively randomized study of 40 healthy, postmenopausal volunteers assigned to four treatment groups: placebo, intramuscular E

resultsTreatment with E

conclusionIn this study, there were individual and interactive effects of E

Indexed as

humaninflammationlipidssex hormonewomen

Identifiers

PMID29978153
PMCPMC6030831
OpenAlexW2808447723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.