ArticleOpen forum infectious diseases2018
Repeat Syphilis Is More Likely to Be Asymptomatic in HIV-Infected Individuals: A Retrospective Cohort Analysis With Important Implications for Screening.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Routinized Syphilis Screening Among Men Living With Human Immunodeficiency Virus: A Stepped Wedge Cluster Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Article
- Research Advances in Clinical Strategies and Preclinical Models for Syphilis Relapse.Infection and drug resistance · 2025Review
- Article
- Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines.Vaccines · 2024Review
- Management of asymptomatic sexually transmitted infections in Europe: towards a differentiated, evidence-based approach.The Lancet regional health. Europe · 2023Review
- Challenges and Solutions to STI Control in the Era of HIV and STI Prophylaxis.Current HIV/AIDS reports · 2023Review
- Incidence, risk factors, and clinical findings of syphilis among men living with HIV in Croatia during the COVID-19 pandemic.Scientific reports · 2023Observational
- Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections.The Journal of antimicrobial chemotherapy · 2023Review
- Clinical and immunological characteristics of HIV/syphilis co-infected patients following long-term antiretroviral treatment.Frontiers in public health · 2023Article
- Previous Syphilis Alters the Course of Subsequent Episodes of Syphilis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Correlates of prevalent syphilis infection among men who have sex with men (MSM) living with HIV attending the HIV clinic in Trinidad.PloS one · 2022Article
- A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines.Pathogens (Basel, Switzerland) · 2021Review
- Patient perspectives on the implementation of routinised syphilis screening with HIV viral load testing: Qualitative process evaluation of the Enhanced Syphilis Screening Among HIV-positive Men trial.BMC health services research · 2021Article
- Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV.Case reports in infectious diseases · 2021Article
- Asymptomatic neurosyphilis may need early intervention in people living with HIV.Chinese medical journal · 2020Article
- Role of IgM testing in the diagnosis and post-treatment follow-up of syphilis: a prospective cohort study.BMJ open · 2020Article
- Repeated Syphilis Episodes in HIV-Infected Men Who Have Sex With Men: A Multicenter Prospective Cohort Study on Risk Factors and the Potential Role of Syphilis Immunity.Open forum infectious diseases · 2020Article
- Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/Frontiers in medicine · 2020Article
- Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study.BMC infectious diseases · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is conflicting evidence as to whether repeat syphilis is more likely to present asymptomatically than initial syphilis. If it is, then this would motivate more frequent and long-term syphilis screening in persons with a history of multiple episodes of syphilis. We conducted detailed folder reviews of all individuals with 4 or more diagnoses of syphilis between 2000 and 2017 at the Institute of Tropical Medicine, Antwerp, and assessed if there was a difference in the proportion presenting with symptomatic (primary and secondary) vs asymptomatic (latent) syphilis in initial vs repeat syphilis. Forty-five clients with 4 or more episodes of syphilis were included in the study. All were HIV-infected. Repeat episodes of syphilis were less likely to be symptomatic than initial episodes (35/160 [21.9%] vs 28/45 [62.2%];
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