Evidence map›Paper›PMID 29977919›Full record

SynthesisBioMed research international2018

Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis.

Shuai Zhou, Chengjia Sun, Shaohui Huang, Ximing Wu, Yan Zhao, Chunling Pan, Hongyan Wang, Junchao Liu, Qian Li, Yurong Kou

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. PRP and PRF-Subgroups and Divisions When Used in Dentistry.Journal of personalized medicine · 2021
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shuai ZhouDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Chengjia SunDepartment of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Shaohui HuangDepartment of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Ximing WuDepartment of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Yan ZhaoDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Chunling PanDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.ORCID 0000-0002-3835-9719
Hongyan WangDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.ORCID 0000-0003-4745-2760
Junchao LiuDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Qian LiDepartment of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Yurong KouDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.ORCID 0000-0003-0249-4481
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLots of bioactive materials have been additionally applied for the treatment of periodontal intrabony defect. However, there is dearth of studies to systematically evaluate the supplementary role of them in periodontal regeneration. The goal of this meta-analysis is to evaluate the adjunctive effects of bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) on the outcomes of bone grafting treatment for periodontal intrabony defects.

methodsArticles published before December 2017 were searched electronically in three databases (PubMed, Embase, and Cochrane Central), with no date or language limits. Randomized controlled trials (RCTs) on the assessment of effectiveness of the four biomaterials in conjunction with demineralized freeze-dried bone allografts (DFDBA) in the treatment of periodontal intrabony defects were enrolled in this meta-analysis. Data were analyzed with STATA 12.

resultsNine studies were included. PRF and PRP significantly improved pocket depth (PD) reduction and clinical attachment loss (CAL) gain. Only PRF exhibited a positive result in recession reduction (RecRed). Only PRP showed a statistically significant increase in bone fill. AM merely gained more CAL. EMD did not improve any clinical outcome.

conclusionOur data suggest that PRF/PRP could be taken as a preferred adjunct to facilitate periodontal regeneration of intrabony defects.

Indexed as

Bone RegenerationPlatelet-Rich PlasmaAdultAgedAlveolar Bone LossDental Enamel ProteinsFemaleGuided Tissue Regeneration, PeriodontalHumansMaleMiddle AgedPeriodontal Attachment LossRandomized Controlled Trials as TopicDental Enamel Proteins

Identifiers

PMID29977919
PMCPMC5994283
OpenAlexW2803356650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.