ArticleCase reports in hematology2018
Multiple Liver Nodules Mimicking Metastatic Disease as Initial Presentation of Multiple Myeloma.
Article in Case reports in hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Article
- Anaplastic Multiple Myeloma Presenting as Acute Liver Failure: A Case Report.Gastro hep advances · 2025Article
- Hepatic involvement as an initial manifestation of multiple myeloma: a case report with atypical imaging features.Frontiers in oncology · 2025Article
- Extraosseous Plasmacytomas: A Radiologist's Perspective-A Narrative Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Review
- Hypervascular nodular hepatic involvement in multiple myeloma: A case report.Journal of clinical imaging science · 2023Article
- O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination.Journal of experimental & clinical cancer research : CR · 2021Article
- Extramedullary Disease in Multiple Myeloma.Current hematologic malignancy reports · 2020Review
- Liver failure due to relapsed myeloma and hepatic iron overload.Ecancermedicalscience · 2020Article
- A Case with Hepatic Involvement Mimicking Metastatic Disease in Multiple Myeloma.Case reports in hematology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple myeloma is a malignant clonal proliferation of plasma cells in the bone marrow preceded by monoclonal gammopathy of undetermined significance. Initial presentation of multiple myeloma as extramedullary spread in soft tissues particularly in the liver is uncommon. We report a case of a 74-year-old African American female who presented with epigastric pain, hematemesis, elevated alkaline phosphatase, and gamma-glutamyl transferase. Initial impression was peptic ulcer disease; however, ultrasound and CT scan of the abdomen showed multiple liver nodules and perihepatic lymphadenopathy suggestive of metastatic disease. Biopsy of the liver nodules showed CD138 and kappa light chain-restricted positive cells consistent with extramedullary spread of multiple myeloma to the liver. The patient achieved partial response after 6 months of treatment with Velcade, cyclophosphamide, and dexamethasone (VCD). Due to severe neutropenia from cyclophosphamide, regimen was switched to Velcade, Revlimid, and dexamethasone (VRD) which resulted to very good partial response in 1 year which eventually persisted after 4 years. No controlled prospective studies have defined the standard treatment for multiple myeloma with extramedullary spread particularly to the liver. Treatment of multiple myeloma with extramedullary disease follows guidelines for multiple myeloma.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.