Evidence map›Paper›PMID 29977578›Full record

ArticleOxford medical case reports2018

Nonbacterial thrombotic endocarditis in a patient with primary antiphospholipid syndrome.

Natee Sirinvaravong, Mary C Rodriguez Ziccardi, Soumya Patnaik, Mahek Shah, Gustavo Fernandez, Jose-Nitram Aliling, Alexander Rubin

Open access · goldAbstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Recurrent nonbacterial thrombotic endocarditis and stroke on anticoagulation.Journal of community hospital internal medicine perspectives · 2020
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Natee SirinvaravongDepartment of Medicine, Einstein Medical Center, Philadelphia, PA, USA.ORCID 0000-0003-4134-0004
Mary C Rodriguez ZiccardiDepartment of Medicine, Einstein Medical Center, Philadelphia, PA, USA.
Soumya PatnaikDivision of Cardiology, University of Texas Health Science Center at Houston, Houston, TX, USA.
Mahek ShahDivision of Cardiology, Lehigh Valley Healthcare Network, Allentown, PA, USA.
Gustavo FernandezDivision of Pulmonology, Temple University Hospital, Philadelphia, PA, USA.
Jose-Nitram AlilingDivision of Rheumatology, University of California, Los Angeles, CA, USA.
Alexander RubinDivision of Cardiology, Pennsylvania Heart and Vascular Group, Jenkintown, Philadelphia PA, USA.
Einstein Medical Center Philadelphia · USTemple University Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonbacterial thrombotic endocarditis (NBTE) is described in patients with mucin-producing cancers and connective tissue disorders (usually SLE). We report NBTE in the setting of primary antiphospholipid antibody syndrome (APS). A 65-year-old female with APS was incidentally found to have thickened mitral leaflets on transthoracic echocardiogram with no signs of infection. Transesophageal echocardiogram (TEE) showed a mobile mitral mass (1.4 × 0.7 cm) and moderate mitral regurgitation. Differential diagnoses included bacterial endocarditis, NBTE, thrombus or tumor. Given the history of primary APS, the absence of fever and negative blood cultures, NBTE was considered. Low-molecular-weight heparin, hydroxychloroquine and corticosteroid were initiated. Repeat TEE in a week revealed shrinkage of the mass (0.6 × 0.7 cm), indicating an inflammatory nature. Lifelong anticoagulation is indicated regardless of embolism occurrence. Hydroxychloroquine and corticosteroids may have roles in the treatment. Determining and treating the underlying etiology is important.

Indexed as

anticoagulantsantiphospholipid syndromehydroxychloroquinenonbacterial thrombotic endocarditisprednisone

Identifiers

PMID29977578
PMCPMC6016692
OpenAlexW2810168832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.