ArticleExperimental and therapeutic medicine2018
Protective effect of Fructus corni polysaccharide on hippocampal tissues and its relevant mechanism in epileptic rats induced by lithium chloride-pilocarpine.
Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review.Frontiers in nutrition · 2023Review
- Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Optimization of Spray-Drying Process Parameters to Study Anti-Sticking Effect of Hydroxypropyl Methyl Cellulose-VLV on Corni fructus Extracts.AAPS PharmSciTech · 2022Article
- Polysaccharides, Next Potential Agent for the Treatment of Epilepsy?Frontiers in pharmacology · 2022Article
- Adaptogenic effects ofJournal of ginseng research · 2021Review
- Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish.BioMed research international · 2020Article
- The Antagonism of 5-HT6 Receptor Attenuates Current-Induced Spikes and Improves Long-Term PotentiationFrontiers in pharmacology · 2020Article
- Polysaccharides ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Corni Fructus attenuates testosterone-induced benign prostatic hyperplasia by suppressing 5α-reductase and androgen receptor expression in rats.Nutrition research and practice · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate the potential effect of Fructus corni polysaccharide (PFC) on the hippocampus tissues in epileptic rats induced by lithium chloride-pilocarpine, and to explore the underlying mechanism. The epileptic rat models were established using lithium chloride-pilocarpine treatment. According to the dosage of PFC, the rat models were divided into three groups: The low-dose (100 mg/kg/day), middle-dose (200 mg/kg/day) and high-dose (300 mg/kg/day) groups. The intervention for rat models lasted for 24 days. Subsequently, the production levels of reactive oxygen species (ROS) and malondialdehyde (MDA), the activity of superoxide dismutase (SOD), the mitochondrial membrane potential and the expressions of mitogen-activated protein kinase [P-38, Janus kinase (JNK) and extracellular signal-regulated kinase 1/2], cytochrome-C and caspase-3 in hippocampal tissues were detected. In addition, the structure of the CA-1 region of the hippocampus was also observed. Compared with the control group, the production levels of ROS were increased and the mitochondrial membrane potential was decreased in the hippocampus tissues of rats in the model group. In addition, in the model group, it was observed that MDA content was increased, SOD activity was decreased, and the expressions of phosphorylated (p)-p38, p-JNK, cytochrome-c and caspase-3 were increased, compared with the control group. Furthermore, those abnormal variations of the indicators were reversed by the intervention of PFC. These findings suggest that PFC can ameliorate the secondary damage to the hippocampi of epileptic rats, and that the anti-oxidation and -apoptosis effects of PFC may be associated with the mechanism that provides a protective effect for hippocampal tissues.
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