Evidence map›Paper›PMID 29977237›Full record

ArticleFrontiers in immunology2018

Phenotype, Function, and Mobilization of 6-Sulfo LacNAc-Expressing Monocytes in Atopic Dermatitis.

Wojciech Baran, Stephanie Oehrl, Fareed Ahmad, Thomas Döbel, Christina Alt, Angelika Buske-Kirschbaum, Marc Schmitz, Knut Schäkel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Revisiting Atopy: The IgE-Dependent Amplification Loop as a Forgotten Driver of Atopic Dermatitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Article
  3. Regulatory Effects of CD14Journal of immunology research · 2026
    Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Wojciech BaranDepartment of Dermatology, Venerology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Stephanie OehrlDepartment of Dermatology, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Fareed AhmadDepartment of Dermatology, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Thomas DöbelDepartment of Dermatology, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Christina AltDepartment of Dermatology, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Angelika Buske-KirschbaumDepartment of Biopsycology, Technical University of Dresden, Dresden, Germany.
Marc SchmitzInstitute of Immunology, Medical Faculty, Technical University of Dresden, Dresden, Germany.
Knut SchäkelDepartment of Dermatology, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DETechnische Universität Dresden · DEWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mononuclear phagocytes (MPs) are important immune regulatory cells in atopic dermatitis (AD). We previously identified 6-sulfo LacNAc-expressing monocytes (slanMo) as TNF-α- and IL-23-producing cells in psoriatic skin lesions and as inducers of IFN-γ-, IL-17-, and IL-22-producing T cells. These cytokines are also upregulated in AD and normalize with treatment, as recently shown for dupilumab-treated patients. We here asked for the role of slanMo in AD. Increased numbers of slanMo were found in AD skin lesions. In difference to other MPs in AD, slanMo lacked expression of FcɛRI, CD1a, CD14, and CD163. slanMo from blood of patients with AD expressed increased levels of CD86 and produced IL-12 and TNF-α at higher amounts than CD14

Indexed as

6-sulfo LacNAc-expressing monocytesatopic dermatitisCD86dendritic cellsIL-12immunologyinflammation

Identifiers

PMID29977237
PMCPMC6021776
OpenAlexW2806843759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.