Evidence map›Paper›PMID 29977196›Full record

ArticleFrontiers in human neuroscience2018

Effects of Transcutaneous Vagus Nerve Stimulation (tVNS) on the P300 and Alpha-Amylase Level: A Pilot Study.

Carlos Ventura-Bort, Janine Wirkner, Hannah Genheimer, Julia Wendt, Alfons O Hamm, Mathias Weymar

Abstract read
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In one paragraph

Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Transcutaneous vagus nerve stimulation and exercise-induced autonomic regulation: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carlos Ventura-BortDepartment of Psychology, University of Potsdam, Potsdam, Germany.
Janine WirknerDepartment of Psychology, University of Greifswald, Greifswald, Germany.
Hannah GenheimerDepartment of Psychology, University of Würzburg, Würzburg, Germany.
Julia WendtDepartment of Psychology, University of Greifswald, Greifswald, Germany.
Alfons O HammDepartment of Psychology, University of Greifswald, Greifswald, Germany.
Mathias WeymarDepartment of Psychology, University of Potsdam, Potsdam, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research suggests that the P3b may be closely related to the activation of the locus coeruleus-norepinephrine (LC-NE) system. To further study the potential association, we applied a novel technique, the non-invasive transcutaneous vagus nerve stimulation (tVNS), which is speculated to increase noradrenaline levels. Using a within-subject cross-over design, 20 healthy participants received continuous tVNS and sham stimulation on two consecutive days (stimulation counterbalanced across participants) while performing a visual oddball task. During stimulation, oval non-targets (standard), normal-head (easy) and rotated-head (difficult) targets, as well as novel stimuli (scenes) were presented. As an indirect marker of noradrenergic activation we also collected salivary alpha-amylase (sAA) before and after stimulation. Results showed larger P3b amplitudes for target, relative to standard stimuli, irrespective of stimulation condition. Exploratory

Indexed as

EEGlocus coeruleusnorepinephrineP300salivary alpha-amylasetVNS

Identifiers

PMID29977196
PMCPMC6021745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.