Evidence map›Paper›PMID 29977153›Full record

ArticleMediators of inflammation2018

CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-

Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yisong QianInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Chuqiao ChenInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Leliang MaInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Ziwei WangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Ling-Fang WangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-2683-1529
Li ZuoInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Yaqin YangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Xiang HuangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Meixiu JiangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.ORCID 0000-0001-8747-6877
Xiaolei WangInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.
Huidong ShiGeorgia Cancer Center, Augusta University, Augusta, GA 30912, USA.
Mingui FuDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Ke-Yu DengInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.ORCID 0000-0003-4802-5074
Hong-Bo XinInstitute of Translational Medicine, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-4257-207X
Nanchang University · CNAugusta University Health · USUniversity of Missouri–Kansas City · US

Funding

Post-transcriptional Regulation of Cytokine ProductionR21AI103618 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI FU, MINGUI · 2014 to 2015
$415k
NIAID NIH HHS R21 AI103618
6 · The paper itself

Abstract

CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. Here, we showed the downregulations of both TLR2 mRNA and protein in macrophages from CD38

Indexed as

ADP-ribosyl Cyclase 1AnimalsBlotting, WesternComputational BiologyInflammationMacrophagesMacrophages, PeritonealMiceNF-kappa BRAW 264.7 CellsSignal TransductionSirtuin 1Toll-Like Receptor 2ADP-ribosyl Cyclase 1NF-kappa BSirt1 protein, mouseSirtuin 1Toll-Like Receptor 2

Identifiers

PMID29977153
PMCPMC6011090
OpenAlexW2804384754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.