ArticleScientific reports2018
Age at first birth in women is genetically associated with increased risk of schizophrenia.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.BMC psychiatry · 2024Pooled it
- Sex Differences in Schizophrenia Across the Reproductive Lifespan.Current psychiatry reports · 2026Review
- Association between age at first birth and postpartum depression: A two-sample mendelian randomization analysis.Heliyon · 2023Article
- Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan.Molecular psychiatry · 2022Article
- Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.Nature communications · 2021Article
- Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.Schizophrenia research · 2021Review
- Using genetics for social science.Nature human behaviour · 2020Review
- Association of Grandparental and Parental Age at Childbirth With Autism Spectrum Disorder in Children.JAMA network open · 2020Article
- Associations of parental age with offspring all-cause and cause-specific adult mortality.Scientific reports · 2019Article
- The genetic relationship between female reproductive traits and six psychiatric disorders.Scientific reports · 2019Article
- Schizophrenia risk and reproductive success: a Mendelian randomization study.Royal Society open science · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
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