Evidence map›Paper›PMID 29977056›Full record

ArticleScientific reports2018

The multidomain flavodiiron protein from Clostridium difficile 630 is an NADH:oxygen oxidoreductase.

Filipe Folgosa, Maria C Martins, Miguel Teixeira

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Hydroxo-bridged active site of flavodiiron NO reductase revealed by NRVS and DFT.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Journal of bacteriology · 2025
    Review
  5. An iron-sulfur cluster as a new metal center in a flavodiiron protein.Protein science : a publication of the Protein Society · 2025
    Article
  6. Article
  7. Impacts ofJournal of bacteriology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Journal of bacteriology · 2024
    Article
  12. Article
  13. Article
  14. Bioenergetics and Reactive Nitrogen Species in Bacteria.International journal of molecular sciences · 2022
    Review
  15. Microbial genomics · 2021
    Article
  16. Article
  17. Plants (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Filipe FolgosaInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal.
Maria C MartinsInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal.ORCID 0000-0002-0900-6287
Miguel TeixeiraInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal. miguel@itqb.unl.pt.ORCID 0000-0003-4124-6237
Universidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavodiiron proteins (FDPs) are enzymes with a minimal core of two domains: a metallo-β-lactamase-like, harbouring a diiron center, and a flavodoxin, FMN containing, domains. FDPs are O

Indexed as

Amino Acid SequenceAnaerobiosisBacterial ProteinsBiocatalysisClostridioides difficileFlavoproteinsHydrogen PeroxideIronNADNitric OxideOxidation-ReductionOxidoreductasesOxygenProtein DomainsSpectrophotometry, UltravioletBacterial ProteinsFlavoproteinsHydrogen PeroxideIronNADNitric OxideOxidoreductasesOxygen

Identifiers

PMID29977056
PMCPMC6033852
OpenAlexW2809697921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.