ArticleScientific reports2018
Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 38 citations in OpenAlex.
- Characterization of novel macrophage cell lines derived from goat and sheep blood and their susceptibility to ruminant virus infections.Microbiology spectrum · 2026Article
- Establishment of a novel immortalized cell line derived from porcine plasmacytoid dendritic cells.In vitro cellular & developmental biology. Animal · 2026Article
- IL-4-mediated monocyte differentiation modulates CD163 expression and PRRSV infection.Frontiers in microbiology · 2026Article
- Article
- Nationwide emergence and spread of highly virulent PRRSV-2 mutants in Korea.Porcine health management · 2025Article
- Recruitment of pulmonary intravascular macrophages in SARS-CoV-2 infected hamsters.Cell and tissue research · 2025Article
- Preconditioning donors with corticosteroids improves early lung graft immunity.Frontiers in immunology · 2025Article
- Mitochondrial dysfunction in PRRSV-2-infected macrophages.Frontiers in immunology · 2025Article
- A Comprehensive Review on Porcine Reproductive and Respiratory Syndrome Virus with Emphasis on Immunity.Vaccines · 2024Review
- Tissue and cellular tropism ofVeterinary pathology · 2024Article
- High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1.Nature communications · 2024Article
- Histopathological characteristics of PRRS and expression profiles of viral receptors in the piglet immune system.Frontiers in veterinary science · 2024Article
- Establishment and characterization of an immortalized red river hog blood-derived macrophage cell line.Frontiers in immunology · 2024Article
- Formononetin and mizoribine inhibit Porcine Reproductive and Respiratory Syndrome Virus replicationFrontiers in nutrition · 2024Article
- Pathological observation and transcriptomic analysis of thymus injury in PRRSV-infected piglets.Veterinary research communications · 2023Article
- Review
- Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination.Vaccines · 2023Review
- Article
- The role of lung macrophages in acute respiratory distress syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Immune cell composition of the bronchoalveolar lavage fluid in healthy and respiratory diseased dromedary camels.BMC veterinary research · 2022Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophages (PIM) identity. PIM have been described microscopically long time ago in species from the Laurasiatheria superorder such as bovine, swine, cats or cetaceans. We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen. Moreover, whereas PRRSV was thought to mainly target AM, we observed that PIM were a major producer of virus. The PIM infection was more correlated with viremia in vivo than AM infection. Finally like AM, PIM-expressed genes were characteristic of an embryonic monocyte-derived macrophage population, whose turnover is independent of bone marrow-derived hematopoietic precursors. This last observation raised the interesting possibility that AM and PIM originate from the same lung precursor.
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