ArticleScientific reports2018
Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Revisiting Algorithms, Tools, and Applications for Sequence and Phylogenetic Analyses in the NGS-Based Omics Era.Biochemical genetics · 2026Review
- Bio-guided discovery of antibacterial metabolites fromJournal of enzyme inhibition and medicinal chemistry · 2025Article
- Marine Fungal Metabolites: A Promising Source for Antibiofilm Compounds.Molecules (Basel, Switzerland) · 2025Review
- Phenotypic and omics analyses of the SordariomycetesmSystems · 2025Article
- Marine endophytes: biosynthetic engines for novel bioactive metabolites.Frontiers in microbiology · 2025Review
- Genome Annotation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic FungiMarine drugs · 2024Article
- Marine fungi: A treasure trove of novel natural products and for biological discovery.PLoS pathogens · 2023Article
- Anti-Candidal Marine Natural Products: A Review.Journal of fungi (Basel, Switzerland) · 2023Review
- Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure-activity relationship, and biosynthesis.Archives of pharmacal research · 2023Review
- Genomic insights intoFrontiers in microbiology · 2023Article
- Application of Gene Knockout and Heterologous Expression Strategy in Fungal Secondary Metabolites Biosynthesis.Marine drugs · 2022Review
- Induction of Isochromanones by Co-Cultivation of the Marine FungusInternational journal of molecular sciences · 2022Article
- Optimization of Protoplast Preparation and Establishment of Genetic Transformation System of an Arctic-Derived FungusFrontiers in microbiology · 2022Article
- Insights onJournal of fungi (Basel, Switzerland) · 2021Article
- Infection Process and Genome Assembly Provide Insights into the Pathogenic Mechanism of Destructive MycoparasiteJournal of fungi (Basel, Switzerland) · 2021Article
- Potential of Anti-Cancer Activity of Secondary Metabolic Products from Marine Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Genomics- and Metabolomics-Based Investigation of the Deep-Sea Sediment-Derived Yeast,Marine drugs · 2020Article
- Characterization of the CAZy Repertoire from the Marine-Derived FungusMarine drugs · 2020Article
- Genomic and transcriptomic survey of an endophytic fungus Calcarisporium arbuscula NRRL 3705 and potential overview of its secondary metabolites.BMC genomics · 2020Article
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11 authors.
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Abstract
Marine Fungi are potent secondary metabolite producers. However, limited genetic information are available their biosynthetic gene clusters (BGCs) and their biotechnological applications. To overcome this lack of information, herein, we used next-generation sequencing methods for genome sequencing of two marine fungi, isolated from the German Wadden Sea, namely Calcarisporium sp. KF525 and Pestalotiopsis sp. KF079. The assembled genome size of the marine isolate Calcarisporium sp. KF525 is about 36.8 Mb with 60 BGCs, while Pestalotiopsis sp. KF079 has a genome size of 47.5 Mb harboring 67 BGCs. Of all BGCs, 98% and 97% are novel clusters of Calcarisporium sp. and Pestalotiopsis sp., respectively. Only few of the BGCs were found to be expressed under laboratory conditions by RNA-seq analysis. The vast majority of all BGCs were found to be novel and unique for these two marine fungi. Along with a description of the identified gene clusters, we furthermore present important genomic features and life-style properties of these two fungi. The two novel fungal genomes provide a plethora of new BGCs, which may have biotechnological applications in the future, for example as novel drugs. The genomic characterizations will provide assistance in future genetics and genomic analyses of marine fungi.
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