ArticleScientific reports2018
Modeling erythrocyte electrodeformation in response to amplitude modulated electric waveforms.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Electro-deformation spectroscopy: A unified method for simultaneous electrical and mechanical characterization of single cells.Acta biomaterialia · 2025Article
- Efficient and Shape-Sensitive Manipulation of Nanoparticles by Quasi-Bound States in the Continuum Modes in All-Dielectric Metasurfaces.Micromachines · 2024Article
- Microscale nonlinear electrokinetics for the analysis of cellular materials in clinical applications: a review.Mikrochimica acta · 2021Review
- Dielectrophoresis Separation of Platelets Using a Novel Zigzag Microchannel.Micromachines · 2020Article
- Determination of Dielectric Properties of Cells using AC Electrokinetic-based Microfluidic Platform: A Review of Recent Advances.Micromachines · 2020Review
- Mechanical fatigue of human red blood cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electrical Impedance Characterization of Erythrocyte Response to Cyclic Hypoxia in Sickle Cell Disease.ACS sensors · 2019Article
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Authors and funding
5 authors.
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Abstract
We present a comprehensive theoretical-experimental framework for quantitative, high-throughput study of cell biomechanics. An improved electrodeformation method has been developed by combing dielectrophoresis and amplitude shift keying, a form of amplitude modulation. This method offers a potential to fully control the magnitude and rate of deformation in cell membranes. In healthy human red blood cells, nonlinear viscoelasticity of cell membranes is obtained through variable amplitude load testing. A mathematical model to predict cellular deformations is validated using the experimental results of healthy human red blood cells subjected to various types of loading. These results demonstrate new capabilities of the electrodeformation technique and the validated mathematical model to explore the effects of different loading configurations on the cellular mechanical behavior. This gives it more advantages over existing methods and can be further developed to study the effects of strain rate and loading waveform on the mechanical properties of biological cells in health and disease.
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