ReviewJournal of clinical medicine2018
Effects of Low Energy Availability on Reproductive Functions and Their Underlying Neuroendocrine Mechanisms.
Review in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Sexual Dimorphism and Menopausal Transition: A Narrative Review of the Metabolic and Physical Effects of Intermittent Fasting.Nutrients · 2026Review
- Reconsidering the life-course implications of relative energy deficiency in sport on pregnancy outcomes.Journal of sport and health science · 2026Article
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
- Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- The lasting impacts of relative energy deficiency in sport imposed on pregnancy health outcomes: A survey-based investigation.Journal of sport and health science · 2025Article
- Molecular Characterization of Hypothalamic-Pituitary-Ovarian Axis Regulation in the Manchurian Zokor (Genes · 2025Article
- Caloric Restriction, the Menstrual Cycle, and Sleep in Women Without Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- Exploring the Relationship Between Eating Disorders and Reproductive Health, with a Focus on Fertility, Obstetric, and Fetal Outcomes: A Narrative Review.Current nutrition reports · 2025Review
- Beyond Menstrual Dysfunction: Does Altered Endocrine Function Caused by Problematic Low Energy Availability Impair Health and Sports Performance in Female Athletes?Sports medicine (Auckland, N.Z.) · 2024Review
- Functional Hypothalamic Amenorrhea and Preclinical Cardiovascular Disease.The Journal of clinical endocrinology and metabolism · 2023Article
- Functional Hypothalamic Amenorrhea: Recognition and Management of a Challenging Diagnosis.Mayo Clinic proceedings · 2023Review
- Article
- The Impact of Competitive Swimming on Menstrual Cycle Disorders and Subsequent Sports Injuries as Related to the Female Athlete Triad and on Premenstrual Syndrome Symptoms.International journal of environmental research and public health · 2022Article
- From Reductionism Toward Integration: Understanding How Social Behavior Emerges From Integrated Circuits.Frontiers in integrative neuroscience · 2022Review
- Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition.Endocrinology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that metabolic disturbances suppress reproductive functions in females. The mechanisms underlying metabolic and nutritional effects on reproductive functions have been established based on a large body of clinical and experimental data. From the 1980s to 1990s, it was revealed that disrupted gonadotropin-releasing hormone (GnRH) secretion is the main cause of reproductive impairments in metabolic and nutritional disorders. From the late 1990s to early 2000s, it was demonstrated that, in addition to their primary functions, some appetite- or metabolism-regulating factors affect GnRH secretion. Furthermore, in the early 2000s, kisspeptin, which is a potent positive regulator of GnRH secretion, was newly discovered, and it has been revealed that kisspeptin integrates the effects of metabolic status on GnRH neurons. Recent studies have shown that kisspeptin mediates at least some of the effects of appetite- and metabolism-regulating factors on GnRH neurons. Thus, kisspeptin might be a useful clinical target for treatments aimed at restoring reproductive functions in individuals with metabolic or nutritional disturbances, such as those who exercise excessively, experience marked weight loss, or suffer from eating disorders. This paper presents a review of what is currently known about the effects of metabolic status on reproductive functions and their underlying mechanisms by summarizing the available evidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.