Evidence map›Paper›PMID 29976853›Full record

ReviewAntioxidants (Basel, Switzerland)2018

Reactive Oxygen and Nitrogen Species Regulate Key Metabolic, Anabolic, and Catabolic Pathways in Skeletal Muscle.

Roland Nemes, Erika Koltai, Albert W Taylor, Katsuhiko Suzuki, Ferenc Gyori, Zsolt Radak

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Roland NemesFaculty of Sports and Health Studies, Hosei University, Tokyo 194-0298, Japan. nem_roland@hosei.ac.jp.
Erika KoltaiResearch Institute of Sport Science, University of Physical Education, Alkotas u. 44, H-1123 Budapest, Hungary. koltaie@gmail.com.
Albert W TaylorFaculty of Health Sciences, The University of Western Ontario, London, ON N6G 1H1, Canada. ataylor2@uwo.ca.
Katsuhiko SuzukiFaculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan. katsu.suzu@waseda.jp.ORCID 0000-0002-6572-5809
Ferenc GyoriInstitute of Sport Science, University of Szeged, H-6726 Szeged, Hungary. gyori@jgypk.szte.hu.
Zsolt RadakResearch Institute of Sport Science, University of Physical Education, Alkotas u. 44, H-1123 Budapest, Hungary. radak@tf.hu.
University of Szeged · HUHosei University · JPHungarian University of Sports Science · HUWaseda University · JPWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen and nitrogen species (RONS) are important cellular regulators of key physiological processes in skeletal muscle. In this review, we explain how RONS regulate muscle contraction and signaling, and why they are important for membrane remodeling, protein turnover, gene expression, and epigenetic adaptation. We discuss how RONS regulate carbohydrate uptake and metabolism of skeletal muscle, and how they indirectly regulate fat metabolism through silent mating type information regulation 2 homolog 3 (SIRT3). RONS are causative/associative signaling molecules, which cause sarcopenia or muscle hypertrophy. Regular exercise influences redox biology, metabolism, and anabolic/catabolic pathways in skeletal muscle in an intensity dependent manner.

Indexed as

oxidative stressskeletal muscle adaptationtraining

Identifiers

PMID29976853
PMCPMC6071245
OpenAlexW2811355327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.