ArticleAJNR. American journal of neuroradiology2018
Impact of Focal White Matter Damage on Localized Subcortical Gray Matter Atrophy in Multiple Sclerosis: A 5-Year Study.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dementia in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.Communications medicine · 2026Article
- Neuroimaging phenotype characterization of early aggressive and late severe multiple sclerosis: a case-control study.Brain communications · 2025Article
- Neuroimaging assessment of facility-bound severely-affected MS reveals the critical role of cortical gray matter pathology: results from the CASA-MS case-controlled study.Journal of neurology · 2024Article
- Regional white matter and gray matter damage and cognitive performances in multiple sclerosis according to sex.Molecular psychiatry · 2023Article
- Time course of lesion-induced atrophy in multiple sclerosis.Journal of neurology · 2022Article
- Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis.Brain and behavior · 2021Article
- Microstructural MRI Correlates of Cognitive Impairment in Multiple Sclerosis: The Role of Deep Gray Matter.Diagnostics (Basel, Switzerland) · 2021Article
- Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2020Article
- Longitudinal analysis of cerebral aqueduct flow measures: multiple sclerosis flow changes driven by brain atrophy.Fluids and barriers of the CNS · 2020Article
- Thalamic Injury and Cognition in Multiple Sclerosis.Frontiers in neurology · 2020Review
- Relationships Among Circulating Levels of Hemostasis Inhibitors, Chemokines, Adhesion Molecules, and MRI Characteristics in Multiple Sclerosis.Frontiers in neurology · 2020Article
- Serum neurofilament light chain levels associations with gray matter pathology: a 5-year longitudinal study.Annals of clinical and translational neurology · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIt is unclear to what extent subcortical gray matter atrophy is a primary process as opposed to a result of focal white matter damage. Correlations between WM damage and atrophy of subcortical gray matter have been observed but may be partly attributable to indirect relationships between co-occurring processes arising from a common cause. Our aim was to cross-sectionally and longitudinally characterize the unique impact of focal WM damage on the atrophy of connected subcortical gray matter regions, beyond what is explainable by global disease progression. MATERIALS AND
methodsOne hundred seventy-six individuals with MS and 47 healthy controls underwent MR imaging at baseline and 5 years later. Atrophy and lesion-based disruption of connected WM tracts were evaluated for 14 subcortical gray matter regions. Hierarchic regressions were applied, predicting regional atrophy from focal WM disruption, controlling for age, sex, disease duration, whole-brain volume, and T2-lesion volume.
resultsWhen we controlled for whole-brain volume and T2-lesion volume, WM tract disruption explained little additional variance of subcortical gray matter atrophy and was a significant predictor for only 3 of 14 regions cross-sectionally (Δ
conclusionsWM tract disruption accounts for a small percentage of atrophy in connected subcortical gray matter when controlling for overall disease burden and is not the primary driver in most cases.
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