Evidence map›Paper›PMID 29976744›Full record

Trial reportHaematologica2018

Prognostic factors of Erdheim-Chester disease: a nationwide survey in Japan.

Takashi Toya, Mizuki Ogura, Kazuhiro Toyama, Akihide Yoshimi, Aya Shinozaki-Ushiku, Akira Honda, Kenjiro Honda, Noriko Hosoya, Yukako Murakami, Hiroyuki Kawashima and 11 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-Based Review.AJNR. American journal of neuroradiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Adult onset xanthogranuloma of the eyelid.American journal of ophthalmology case reports · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Takashi ToyaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Mizuki OguraDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Kazuhiro ToyamaDepartment of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital.
Akihide YoshimiDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Aya Shinozaki-UshikuDepartment of Pathology, Graduate School of Medicine, The University of Tokyo.
Akira HondaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Kenjiro HondaDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine.
Noriko HosoyaLaboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
Yukako MurakamiDepartment of Dermatology, Osaka University Graduate School of Medicine.
Hiroyuki KawashimaDivision of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences.
Yasuhito NannyaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Shunya AraiDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Fumihiko NakamuraDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo.
Yusuke ShinodaDepartment of Rehabilitation Medicine Graduate School of Medicine, The University of Tokyo.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine.
Kiyoshi MiyagawaLaboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
Masashi FukayamaDepartment of Pathology, Graduate School of Medicine, The University of Tokyo.
Akiko Moriya-SaitoClinical Research Center, National Hospital Organization Nagoya Medical Center, Aichi.
Ichiro KatayamaDepartment of Dermatology, Osaka University Graduate School of Medicine.
Takashi OguraDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Mineo KurokawaDepartment of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo kurokawa-tky@umin.ac.jp.
The University of Tokyo · JPOsaka University · JPKanagawa Cardiovascular and Respiratory Center · JPNational Hospital Organization · JPNiigata University · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erdheim-Chester disease is a rare histiocytosis with insufficient clinical data. To clarify the clinical features and prognostic factors of Erdheim-Chester disease, we conducted a nationwide survey to collect the detailed data of 44 patients with Erdheim-Chester disease in Japan. The median age of onset of the participants was 51 (range: 23-76) years, and the median number of involved organs per patient was 4 (range: 1-11). The existence of central nervous system disease was correlated with older age (

Indexed as

Mutation, MissenseAdultAgedAge FactorsAmino Acid SubstitutionDisease-Free SurvivalErdheim-Chester DiseaseFemaleHumansJapanMaleMiddle AgedProto-Oncogene Proteins B-rafSurvival RateBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID29976744
PMCPMC6278973
OpenAlexW2852540589

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.