Evidence map›Paper›PMID 29976738›Full record

ArticleHaematologica2018

Trisomy 12 chronic lymphocytic leukemia expresses a unique set of activated and targetable pathways.

Lynne V Abruzzo, Carmen D Herling, George A Calin, Christopher Oakes, Lynn L Barron, Haley E Banks, Vikram Katju, Michael J Keating, Kevin R Coombes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. An Approach to Diagnosis of Richter Transformation in Chronic Lymphocytic Leukemia.Journal of the advanced practitioner in oncology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lynne V AbruzzoDepartment of Pathology, The Ohio State University, Columbus, OH, USA lynne.abruzzo@osumc.edu.
Carmen D HerlingDepartment I for Internal Medicine and Center of Integrated Oncology, University of Cologne, Germany.
George A CalinDepartment of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Christopher OakesDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Lynn L BarronDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Haley E BanksDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Vikram KatjuDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Michael J KeatingDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kevin R CoombesDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
The Ohio State University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Cologne · DE

Funding

Protein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9M
NCI NIH HHS R01 CA182905
6 · The paper itself

Abstract

Although trisomy 12 (+12) chronic lymphocytic leukemia (CLL) comprises about 20% of cases, relatively little is known about its pathophysiology. These cases often demonstrate atypical morphological and immunophenotypic features, high proliferative rates, unmutated immunoglobulin heavy chain variable region genes, and a high frequency of

Indexed as

Gene Expression Regulation, LeukemicTrisomy5'-NucleotidaseAdultAgedAged, 80 and overChromosomes, Human, Pair 12FemaleGene Expression ProfilingGPI-Linked ProteinsHumansImmunoglobulin Variable RegionKaplan-Meier EstimateLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle Aged5'-NucleotidaseGPI-Linked ProteinsImmunoglobulin Variable RegionNFATC Transcription FactorsNT5E protein, humanReceptor, Notch1

Identifiers

PMID29976738
PMCPMC6269288
OpenAlexW2833348895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.