Evidence map›Paper›PMID 29976695›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Aisling Chaney, Haley C Cropper, Emily M Johnson, Kendra J Lechtenberg, Todd C Peterson, Marc Y Stevens, Marion S Buckwalter, Michelle L James

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  7. Role of Microglia in Stroke.Advances in neurobiology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Direct Comparison of [Molecular imaging and biology · 2022
    Article
  13. Reduced Acquisition Time [Frontiers in medicine · 2022
    Article
  14. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  15. Review
  16. Membrane-embedded TSPO: an NMR view.European biophysics journal : EBJ · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aisling ChaneyDepartment of Radiology, Stanford University, Stanford California.
Haley C CropperDepartment of Radiology, Stanford University, Stanford California.
Emily M JohnsonDepartment of Radiology, Stanford University, Stanford California.
Kendra J LechtenbergDepartment of Neurology and Neurological Sciences, Stanford University, Stanford California; and.
Todd C PetersonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford California; and.
Marc Y StevensDepartment of Radiology, Stanford University, Stanford California.
Marion S BuckwalterDepartment of Neurology and Neurological Sciences, Stanford University, Stanford California; and.
Michelle L JamesDepartment of Radiology, Stanford University, Stanford California mljames@stanford.edu.
Stanford University · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

Neuroinflammation plays a key role in neuronal injury after ischemic stroke. PET imaging of translocator protein 18 kDa (TSPO) permits longitudinal, noninvasive visualization of neuroinflammation in both preclinical and clinical settings. Many TSPO tracers have been developed, however, it is unclear which tracer is the most sensitive and accurate for monitoring the in vivo spatiotemporal dynamics of neuroinflammation across applications. Hence, there is a need for head-to-head comparisons of promising TSPO PET tracers across different disease states. Accordingly, the aim of this study was to directly compare 2 promising second-generation TSPO tracers,

Indexed as

AcetamidesCarbazolesPyrazolesPyrimidinesAcute DiseaseAnimalsBrain IschemiaCarbon RadioisotopesChronic DiseaseDisease Models, AnimalFluorine RadioisotopesInflammationMicePositron-Emission TomographyRadioactive TracersReceptors, GABAAcetamidesBzrp protein, mouseCarbazolesCarbon-11Carbon RadioisotopesFluorine-18Fluorine RadioisotopesGE-180N,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo(1,5-a)pyrimidin-3-yl)-acetamidePyrazolesPyrimidinesRadioactive TracersReceptors, GABAischemic strokeneuroinflammationPETTSPO

Identifiers

PMID29976695
PMCPMC6354224
OpenAlexW2838315183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.