Evidence map›Paper›PMID 29976669›Full record

ArticleJournal of virology2018

Adenovirus E1A Activation Domain Regulates H3 Acetylation Affecting Varied Steps in Transcription at Different Viral Promoters.

Emily Hsu, Mario A Pennella, Nathan R Zemke, Carol Eng, Arnold J Berk

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Global cis-regulatory landscape of double-stranded DNA viruses.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emily HsuMolecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Mario A PennellaDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
Nathan R ZemkeMolecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.
Carol EngDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
Arnold J BerkMolecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA berk@mbi.ucla.edu.
University of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
BIOSYNTHESIS OF ADENOVIRUS EARLY RNASR37CA025235 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERK, ARNOLD J · 1987 to 2011
$7.8M
BIOSYNTHESIS OF ADENOVIRUS EARLY RNASR01CA025235 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERK, ARNOLD J · 1985 to 2016
$2.7M
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA025235NCI NIH HHS R37 CA025235
6 · The paper itself

Abstract

How histone acetylation promotes transcription is not clearly understood. Here, we confirm an interaction between p300 and the adenovirus 2 large E1A activation domain (AD) and map the interacting regions in E1A by observing colocalization at an integrated

Indexed as

Promoter Regions, GeneticTranscription, GeneticAcetylationAdenoviridaeAdenovirus E1A ProteinsCREB-Binding ProteinE1A-Associated p300 ProteinGene Expression RegulationHistonesHumansRNA Polymerase IITranscriptional ActivationAdenovirus E1A ProteinsCREB-Binding ProteinCREBBP protein, humanE1A-Associated p300 ProteinEP300 protein, humanHistonesRNA Polymerase IIadenovirus E1Aadenovirus transcriptionCBPCREBBPEP300histone acetylationp300

Identifiers

PMID29976669
PMCPMC6146688
OpenAlexW2833342287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.