Evidence map›Paper›PMID 29976666›Full record

ArticleJournal of virology2018

Hepacivirus A Infection in Horses Defines Distinct Envelope Hypervariable Regions and Elucidates Potential Roles of Viral Strain and Adaptive Immune Status in Determining Envelope Diversity and Infection Outcome.

Joshua D Ramsay, Ryan Evanoff, Robert H Mealey

RetractedOpen access · bronzeAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua D RamsayDepartment of Veterinary Microbiology and Immunology, Washington State University, Pullman, Washington, USA jdr105@wsu.edu.ORCID https://orcid.org/0000-0002-5871-7296
Ryan EvanoffDepartment of Veterinary Microbiology and Immunology, Washington State University, Pullman, Washington, USA.
Robert H MealeyDepartment of Veterinary Microbiology and Immunology, Washington State University, Pullman, Washington, USA.
Washington State University · US

Funding

Hepacivirus control by T cells and broadly active antibodiesR21AI126304 · NIAID · WASHINGTON STATE UNIVERSITY · PI MEALEY, ROBERT H · 2016 to 2017
$418k
NIAID NIH HHS R21 AI126304
6 · The paper itself

Abstract

Hepacivirus A (also known as nonprimate hepacivirus and equine hepacivirus) is a hepatotropic virus that can cause both transient and persistent infections in horses. The evolution of intrahost viral populations (quasispecies) has not been studied in detail for hepacivirus A, and its roles in immune evasion and persistence are unknown. To address these knowledge gaps, we first evaluated the envelope gene (E1 and E2) diversity of two different hepacivirus A strains (WSU and CU) in longitudinal blood samples from experimentally infected adult horses, juvenile horses (foals), and foals with severe combined immunodeficiency (SCID). Persistent infection with the WSU strain was associated with significantly greater quasispecies diversity than that observed in horses who spontaneously cleared infection (

Indexed as

Adaptive ImmunityViral Envelope ProteinsAnimalsFlaviviridae InfectionsGenetic VariationHepacivirusHorse DiseasesHorsesImmune EvasionQuasispeciesViral Envelope Proteinsequine hepacivirushepacivirushepacivirus Ahepatitishepatitis C virushorsenonprimate hepacivirusquasispecies

Identifiers

PMID29976666
PMCPMC6146699
OpenAlexW2810537194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.