Observational studyThe European respiratory journal2018
Dyspnoea in patients receiving noninvasive ventilation for acute respiratory failure: prevalence, risk factors and prognostic impact: A prospective observational study.
Observational study in The European respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Low dose of morphine to relieve dyspnea in acute respiratory failure: the OpiDys double-blind randomized controlled trial.Respiratory research · 2024Trial
- Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure.Critical care (London, England) · 2024Trial
- Phenotypes of Patients with COVID-19 Who Have a Positive Clinical Response to Helmet Noninvasive Ventilation.American journal of respiratory and critical care medicine · 2022Trial
- Multifaceted regulation of immune cells in radiation-induced pulmonary fibrosis: from mechanistic insights to targeted therapies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure.Annals of intensive care · 2026Article
- Monitoring patients with acute respiratory failure during non-invasive respiratory support to minimize harm and identify treatment failure.Critical care (London, England) · 2025Review
- Nasal High Flow to Modulate Dyspnea in Orally Intubated Weanable Patients.American journal of respiratory and critical care medicine · 2025Article
- Multimodal physiological correlates of dyspnea ratings during breath-holding in healthy humans.European journal of applied physiology · 2025Article
- Response to "Relationships between dyspnea, oxygenation and prognosis in hypoxemic respiratory failure".Critical care (London, England) · 2025Article
- The occurrence mechanism, assessment, and non-pharmacological treatment of dyspnea.Medical review (2021) · 2024Review
- Breathlessness assessment, management and impact in the intensive care unit: a rapid review and narrative synthesis.Annals of intensive care · 2024Review
- Dyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statement.Intensive care medicine · 2024Article
- Assessment of Dyspnea in Critically Ill Patients: A Comparative Analysis of Evaluation Scales.Cureus · 2024Article
- Acute dyspnea in the emergency department: a clinical review.Internal and emergency medicine · 2023Review
- Personalized Respiratory Support in ARDS: A Physiology-to-Bedside Review.Journal of clinical medicine · 2023Review
- High-flow versus Venturi Mask Oxygen Therapy to Prevent Reintubation: A Matter of Time or Device?American journal of respiratory and critical care medicine · 2023Article
- Article
- The Effect of Provision of Information and Supportive Nursing Care on Blood Gas, Vital Signs, Anxiety, Stress, and Agitation Levels in COPD Patients Treated with NIV: A Randomized Controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Factors Associated with and Prognosis Impact of Perceived Sleep Quality and Estimated Quantity in Patients Receiving Non-Invasive Ventilation for Acute Respiratory Failure.Journal of clinical medicine · 2022Article
- Noninvasive respiratory support for acute respiratory failure due to COVID-19.Current opinion in critical care · 2022Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyspnoea is a frequent and intense symptom in intubated patients, but little attention has been paid to dyspnoea during noninvasive mechanical ventilation in the intensive care unit (ICU).The objectives of this study were to quantify the prevalence, intensity and prognostic impact of dyspnoea in patients receiving noninvasive ventilation (NIV) for acute respiratory failure (ARF) based on secondary analysis of a prospective observational cohort study in patients who received ventilatory support for ARF in 54 ICUs in France and Belgium. Dyspnoea was measured by a modified Borg scale.Among the 426 patients included, the median (interquartile range) dyspnoea score was 4 (3-5) on admission and 3 (2-4) after the first NIV session (p=0.001). Dyspnoea intensity ≥4 after the first NIV session was associated with the Sequential Organ Failure Assessment Score (odds ratio (OR) 1.12, p=0.001), respiratory rate (OR 1.03, p=0.032), anxiety (OR 1.92, p=0.006), leaks (OR 2.5, p=0.002) and arterial carbon dioxide tension (OR 0.98, p=0.025). Dyspnoea intensity ≥4 was independently associated with NIV failure (OR 2.41, p=0.001) and mortality (OR 2.11, p=0.009), but not with higher post-ICU burden and altered quality of life.Dyspnoea is frequent and intense in patients receiving NIV for ARF and is associated with a higher risk of NIV failure and poorer outcome.
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