Evidence map›Paper›PMID 29976647›Full record

ArticlemSphere2018

Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.

Andrew Zukauskas, Randall J Mrsny, Paula Cortés Barrantes, Jerrold R Turner, John M Leong, Beth A McCormick

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Andrew ZukauskasDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Randall J MrsnyDepartment of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, United Kingdom.
Paula Cortés BarrantesDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jerrold R TurnerDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
John M LeongDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Beth A McCormickDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA Beth.McCormick@umassmed.edu.
Brigham and Women's Hospital · USUniversity of Massachusetts Chan Medical School · USTufts University · USUniversity of Bath · GB

Funding

ZO-1-MEDIATED PROTEIN INTERACTIONS: REGULATORS AND INTEGRATORS OF DIVERSE EPITHELIAL FUNCTIONS IN HEALTH AND DISEASER01DK061931 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2001 to 2026
$15.0M
Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.R01DK068271 · NIDDK · UNIVERSITY OF CHICAGO · PI JERROLD R. TURNER · 2005 to 2026
$11.3M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
INTESTINAL INFLAMMATION ORCHESTRATED BY PATHOGENSR01DK056754 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCCORMICK, BETH A · 2000 to 2017
$6.5M
Control of Neutrophilic Inflammation in Intestinal Health and DiseaseR01DK109677 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Beth A McCormick · 2016 to 2026
$5.2M
NIDDK NIH HHS R01 DK056754NIDDK NIH HHS R01 DK068271NIDDK NIH HHS R01 DK109677NIDDK NIH HHS R24 DK099803
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell Movement8,11,14-Eicosatrienoic AcidAnimalsATP-Binding Cassette, Sub-Family C ProteinsCell LineDisease Models, AnimalEpithelial CellsHumansLungMiceMultidrug Resistance-Associated Protein 2NeutrophilsPneumonia, PneumococcalRespiratory Mucosa8,11,14-Eicosatrienoic AcidABCC2 protein, humanATP-Binding Cassette, Sub-Family C Proteinshepoxillin A3-Dmultidrug resistance-associated protein 1Multidrug Resistance-Associated Protein 2hepoxilin A3MRP1MRP2neutrophilPMNpneumococcusStreptococcus pneumoniae

Identifiers

PMID29976647
PMCPMC6034076
OpenAlexW2810900482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.