Evidence map›Paper›PMID 29976588›Full record

ArticleJournal of clinical microbiology2018

Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

Margaretha de Vos, Brigitta Derendinger, Tania Dolby, John Simpson, Paul D van Helden, John E Rice, Lawrence J Wangh, Grant Theron, Robin M Warren

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Xpert MTB/RIF Ultra-resistant and MTBDRAntimicrobial agents and chemotherapy · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Use of a FluoroTypeDiagnostics (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaretha de VosDST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Brigitta DerendingerDST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Tania DolbyNational Health Laboratory Services, Green Point, Cape Town, South Africa.
John SimpsonNational Health Laboratory Services, Green Point, Cape Town, South Africa.
Paul D van HeldenDST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
John E RiceDepartment of Biology, Brandeis University, Waltham, Massachusetts, USA.
Lawrence J WanghDepartment of Biology, Brandeis University, Waltham, Massachusetts, USA.
Grant TheronDST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Robin M WarrenDST-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa rw1@sun.ac.za.

Funding

Evaluation of a highly-informative LATE-PCR single-tube assay for M(X)DR-TBR01AI099532 · NIAID · STELLENBOSCH UNIVERSITY · PI WARREN, ROBIN MARK · 2012 to 2015
$521k
6 · The paper itself

Abstract

Most cases of multidrug-resistant (MDR) tuberculosis (TB) are never diagnosed (328,300 of the ∼490,000 cases in 2016 were missed). The Xpert MTB/RIF assay detects resistance only to rifampin, despite ∼20% of rifampin-resistant cases being susceptible to isoniazid (a critical first-line drug). Consequently, many countries require further testing with the GenoType MTBDR

Indexed as

Antitubercular AgentsDrug Resistance, Multiple, BacterialGenes, BacterialGenotyping TechniquesHumansIsoniazidMicrobial Sensitivity TestsMolecular Diagnostic TechniquesMutationMycobacterium tuberculosisReagent Kits, DiagnosticRifampinSensitivity and SpecificitySputumTuberculosis, Multidrug-ResistantAntitubercular AgentsIsoniazidReagent Kits, DiagnosticRifampindiagnosticsdrug resistanceFluoroType MTBDRisoniazidmolecularMycobacterium tuberculosisrifampintuberculosis

Identifiers

PMID29976588
PMCPMC6113470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.