Evidence map›Paper›PMID 29976226›Full record

ArticleArthritis research & therapy2018

Mediation analysis to understand genetic relationships between habitual coffee intake and gout.

Joseph Hutton, Tahzeeb Fatima, Tanya J Major, Ruth Topless, Lisa K Stamp, Tony R Merriman, Nicola Dalbeth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Association of theHeliyon · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joseph HuttonDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand.
Tahzeeb FatimaDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Tanya J MajorDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Ruth ToplessDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Lisa K StampDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Tony R MerrimanDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Nicola DalbethDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand. n.dalbeth@auckland.ac.nz.
University of Otago · NZUniversity of Auckland · NZ

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundIncreased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). The aim of this study was to determine whether these single nucleotide polymorphisms (SNPs) influence the risk of gout through their effects on coffee consumption.

methodsThis research was conducted using the UK Biobank Resource. Data were available for 130,966 European participants aged 40-69 years. Gout status and coffee intake were tested for association with four urate-associated SNPs: GCKR (rs1260326), ABCG2 (rs2231142), MLXIPL (rs1178977), and CYP1A2 (rs2472297). Multiple regression and path analysis were used to examine whether coffee consumption mediated the effect of the SNPs on gout risk.

resultsCoffee consumption was inversely associated with gout (multivariate adjusted odds ratio (95% confidence interval (CI)) for any coffee consumption 0.75 (0.67-0.84, P = 9 × 10

conclusionCoffee consumption is inversely associated with risk of gout. Although alleles at several SNPs associate with both lower coffee consumption and higher risk of gout, these SNPs largely influence gout risk directly, rather than indirectly through effects on coffee consumption.

Indexed as

CoffeePolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAdultAgedAllelesATP Binding Cassette Transporter, Subfamily G, Member 2Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCytochrome P-450 CYP1A2Drinking BehaviorFemaleGene FrequencyGenetic Predisposition to DiseaseGoutHumansMaleABCG2 protein, humanAdaptor Proteins, Signal TransducingATP Binding Cassette Transporter, Subfamily G, Member 2Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCoffeeCytochrome P-450 CYP1A2GCKR protein, humanMLXIPL protein, humanNeoplasm ProteinsUric AcidCoffeeDietGeneticsGoutUrate

Identifiers

PMID29976226
PMCPMC6034252
OpenAlexW2880738946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.