Evidence map›Paper›PMID 29976140›Full record

ArticleBMC gastroenterology2018

Red cell distribution width and red cell distribution width to total serum calcium ratio as major predictors of severity and mortality in acute pancreatitis.

Marta Gravito-Soares, Elisa Gravito-Soares, Dário Gomes, Nuno Almeida, Luís Tomé

Registry-linked trialAbstract read
In one paragraph

Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05480241 (Impact of Exocrine Pancreatic Insufficiency Associated With Acute Pancreatitis and Pancreatic Enzyme Replacement Therapy on Gut Microbiota, Immunological Changes and Quality of Life), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05480241 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Impact of Exocrine Pancreatic Insufficiency Associated With Acute Pancreatitis and Pancreatic Enzyme Replacement Therapy on Gut Microbiota, Immunological Changes and Quality of Life

TypeinterventionalSponsorUnidade Local de Saúde de Coimbra, EPERan2022 to 2024Enrolled84ConditionsAcute Pancreatitis, Exocrine Pancreatic Insufficiency, Gut Microbiota, ImmunologyArmsPancreatic Enzyme Replacement Therapy, Placebo
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marta Gravito-SoaresDepartment of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, 3000-075, Coimbra, Portugal. ms18498@gmail.com.ORCID http://orcid.org/0000-0002-0635-2475
Elisa Gravito-SoaresDepartment of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, 3000-075, Coimbra, Portugal.ORCID http://orcid.org/0000-0002-5220-8757
Dário GomesDepartment of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, 3000-075, Coimbra, Portugal.
Nuno AlmeidaDepartment of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, 3000-075, Coimbra, Portugal.
Luís ToméDepartment of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, 3000-075, Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distribution width (RDW) is a simple and routine parameter that seems to be related to inflammatory status. Our aims were to evaluate the diagnostic value of RDW in severity and mortality of AP comparing with other prognostic scoring systems.

methodsRetrospective case-control study of a total of 312 patients with AP admitted between 2014 and 2016. Patients with severe AP (cases) were compared with patients with mild AP (controls) in the 1:1 proportion. Additionally, a comparison between survivor and nonsurvivor AP patients was performed. Diagnosis and severity of AP were defined according to the revised Atlanta classification 2012. Variables evaluated included demographics, comorbidities, hospital stay, laboratorial parameters, arterial blood gas analysis, prognostic scores within 24 h of admission (Ranson, BISAP and Modified Marshall) and mortality.

resultsIncluded 91 cases of severe AP, most males (58.2% vs 51.6%; p = 0.228) with mean age of 64.8 ± 16.3 years (vs 67.9 ± 13.7; p = 0.239). RDW

conclusionsRDW is a simple routine parameter, available at admission. This AP cohort showed that RDW

Indexed as

Erythrocyte IndicesSeverity of Illness IndexAcute DiseaseAgedArea Under CurveBiomarkersCalciumCase-Control StudiesFemaleHumansMaleMiddle AgedPancreatitisRetrospective StudiesSensitivity and SpecificityBiomarkersCalciumAcute pancreatitisMortalityRed cell distribution widthSeverityTotal serum calcium

Identifiers

PMID29976140
PMCPMC6034316

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.