Evidence map›Paper›PMID 29976100›Full record

Observational studyThe Journal of international medical research2018

Effects of binge alcohol consumption on sleep and inflammation in healthy volunteers.

Amanda N Wilkinson, Majid Afshar, Osman Ali, Waqas Bhatti, Jeffrey D Hasday, Giora Netzer, Avelino C Verceles

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Amanda N Wilkinson1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
Majid Afshar2 Division of Pulmonary & Critical Care Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, USA.
Osman Ali1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
Waqas Bhatti1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
Jeffrey D Hasday1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
Giora Netzer1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
Avelino C Verceles1 Division of Pulmonary & Critical Care Medicine, University of Maryland School of Medicine, Baltimore, USA.
University of Maryland, Baltimore · USLoyola University Chicago · US

Funding

CHANGE OF GRANTEE INSTITUTION 1 K23 AA024503 Alcohol, Burn-Injury, and Acute Respiratory Distress SyndromeK23AA024503 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI AFSHAR, MAJID · 2016 to 2020
$948k
Proinflammatory Effects Of Acute Alcohol Ingestion in HumansF32AA022553 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI AFSHAR, MAJID · 2013 to 2013
$48k
NIAAA NIH HHS F32 AA022553NIAAA NIH HHS K23 AA024503
6 · The paper itself

Abstract

Objective Alcohol is a hypnotic that modifies immune function, specifically the cytokines interferon gamma (IFN-γ) and interleukin 2 (IL-2). We evaluated the association between unscheduled napping and acute alcohol-induced augmentation of IFN-γ and IL-2 expression. Methods In this prospective, observational pilot study, volunteers completed questionnaires on sleep quality, alcohol use, and hangover characteristics. Actigraph recordings began three nights before and continued for four nights after study initiation. Napping was recorded by actigraphy and self-reporting. A weight-based dose of 100-proof vodka was consumed, and the blood alcohol content (BAC) and phytohemagglutinin-M stimulated cytokine level were measured before and 20 minutes, 2 hours, and 5 hours after binge consumption. Results Ten healthy volunteers participated (mean age, 34.4 ± 2.3 years; mean body mass index, 23.9 ± 4.6 kg/m

Indexed as

ActigraphyAdultAlcohol DrinkingBinge DrinkingFemaleHealth SurveysHealthy VolunteersHumansImmunity, InnateInflammationInterferon-gammaInterleukin-2MalePilot ProjectsProspective StudiesSleepInterferon-gammaInterleukin-2alcoholhypnoticsImmunityinsomniapharmacologysleep

Identifiers

PMID29976100
PMCPMC6136031
OpenAlexW2876025175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.