Evidence map›Paper›PMID 29975624›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2018

Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Diffuse Large B-Cell Lymphoma: An Individual Patient-Level Analysis of Multiple Randomized Trials (SEAL).

Qian Shi, Norbert Schmitz, Fang-Shu Ou, Jesse G Dixon, David Cunningham, Michael Pfreundschuh, John F Seymour, Ulrich Jaeger, Thomas M Habermann, Corinne Haioun and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. End Point Surrogacy in First-Line Chronic Lymphocytic Leukemia.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Trial
  10. Maintenance treatment and survival in patients with newly diagnosed diffuse large B cell lymphoma in the immunochemotherapy era: a systematic review and network meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  11. Review
  12. Review
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  19. Development and validation of a [European radiology · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Qian ShiQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Norbert SchmitzQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Fang-Shu OuQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Jesse G DixonQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
David CunninghamQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Michael PfreundschuhQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
John F SeymourQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Ulrich JaegerQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Thomas M HabermannQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Corinne HaiounQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Hervé TillyQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Hervé GhesquieresQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Francesco MerliQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Marita ZiepertQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Raoul HerbrechtQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Jocelyne FlamentQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Tommy FuQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Bertrand CoiffierQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.
Christopher R FlowersQian Shi, Fang-Shu Ou, Jesse G. Dixon, and Thomas M. Habermann, Mayo Clinic, Rochester, MN; Norbert Schmitz, University of Muenster, Muenster; Michael Pfreundschuh, Universität des Saarlandes, Homburg; Marita Ziepert, University of Leipzig, Leipzig, Germany; David Cunningham, The Royal Marsden Hospital, Surrey, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia; Ulrich Jaeger, Medical University of Vienna, Vienna, Austria; Corinne Haioun, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil; Hervé Tilly, Institut National de la Santé et de la Recherche Médicale U1245, Université de Rouen, Rouen; Hervé Ghesquieres and Bertrand Coiffier, Centre Hospitalier Lyon-Sud, Pierre-Benite; Raoul Herbrecht, Hôpital de Hautepierre, Strasbourg, France; Francesco Merli, Azienda Unità Sanitaria Locale-Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy; Jocelyne Flament, Celgene, Boudry, Switzerland; Tommy Fu, Celgene, Summit, NJ; and Christopher R. Flowers, Emory University, Atlanta, GA.

Funding

Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6M
NCI NIH HHS U10 CA180820
6 · The paper itself

Abstract

Purpose Overall survival (OS) is the definitive and best-established primary efficacy end point to evaluate diffuse large B-cell lymphoma (DLBCL) therapies, but it requires prolonged follow-up. An earlier end point assessed post-treatment would expedite clinical trial conduct and accelerate patient access to effective new therapies. Our objective was to formally evaluate progression-free survival (PFS) and PFS at 24 months (PFS24) as surrogate end points for OS in first-line DLBCL. Patients and Methods Individual patient data were analyzed from 7,507 patients from 13 multicenter randomized controlled trials of active treatment in previously untreated DLBCL, published after 2002, with sufficient PFS data to predict treatment effects on OS. Trial-level surrogacy examining the correlation of treatment effect estimates of PFS/PFS24 and OS was evaluated using both linear regression ( R

Indexed as

Antineoplastic AgentsBiomarkersHumansLymphoma, Large B-Cell, DiffuseMulticenter Studies as TopicProgression-Free SurvivalRandomized Controlled Trials as TopicTreatment OutcomeAntineoplastic AgentsBiomarkers

Identifiers

PMID29975624
PMCPMC6532366

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