Evidence map›Paper›PMID 29974837›Full record

ArticleEpidemiology and infection2018

The role of benzathine penicillin G in predicting and preventing all-cause acute respiratory disease in military recruits: 1991-2017.

Jacob D Ball, Mattia A Prosperi, Alfonza Brown, Xinguang Chen, Eben Kenah, Yang Yang, Derek A T Cummings, Caitlin M Rivers

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jacob D BallDepartment of Epidemiology,University of Florida,Gainesville,USA.ORCID 0000-0001-5450-9871
Mattia A ProsperiDepartment of Epidemiology,University of Florida,Gainesville,USA.ORCID 0000-0002-9021-5595
Alfonza BrownU.S. Department of Defense,Army Public Health Center,Army Medical Command,Edgewood,USA.
Xinguang ChenDepartment of Epidemiology,University of Florida,Gainesville,USA.
Eben KenahDepartment of Biostatistics,The Ohio State University,Columbus,USA.
Yang YangEmerging Pathogens Institute,University of Florida,Gainesville,USA.
Derek A T CummingsEmerging Pathogens Institute,University of Florida,Gainesville,USA.
Caitlin M RiversU.S. Department of Defense,Army Public Health Center,Army Medical Command,Edgewood,USA.
United States Army Medical Command · USUniversity of Florida · USUniversity of Florida Health · USThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adenovirus vaccine and benzathine penicillin G (BPG) have been used by the US military to prevent acute respiratory diseases (ARD) in trainees, though these interventions have had documented manufacturing problems. We fit Poisson regression and random forest models (RF) to 26 years of weekly ARD incidence data to explore the impact of the adenovirus vaccine and BPG prophylaxis on respiratory disease burden. Adenovirus vaccine availability was among the most important predictors of ARD in the RF, while BPG was the ninth most important. BPG was a significant protective factor against ARD (incidence rate ratio (IRR) = 0.68; 95% confidence interval (CI) 0.67-0.70), but less so than either the old or new adenovirus vaccine (IRR = 0.39, 95% CI 0.38-0.39 and IRR = 0.11, 95% CI 0.11-0.11), respectively. These results suggest that BPG is moderately predictive of, and significantly protective against ARD, though to a lesser extent than either the old or new adenovirus vaccine.

Indexed as

Antibiotic ProphylaxisMilitary PersonnelAcute DiseaseAnti-Bacterial AgentsHumansModels, TheoreticalPenicillin G BenzathinePoisson DistributionRespiratory Tract InfectionsUnited StatesAnti-Bacterial AgentsPenicillin G BenzathineAdenovirusmilitarypredictive modelsprophylaxisrespiratory disease

Identifiers

PMID29974837
PMCPMC9506690
OpenAlexW2812477616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.